承气方剂预防大鼠肝移植后肝脏缺血/再灌注损伤的实验研究  

Using Chengqi Prescription to Prevent Hepatic Ischemia/Reperfusion Injury after Liver Transplantation in Rats

作　　者：梁法生[1] 宋继昌 高英堂[1] 张文 张志尧 刘丽川 吕文岚 

机构地区：[1]天津医科大学附属第三中心医院

出　　处：《中国中西医结合杂志》2001年第12期920-922,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :观察承气方剂预防大鼠肝移植后肝缺血 /再灌注损伤的作用。方法 :采用大鼠原位肝移植模型 ,随机分组 ,即中药组、多粘菌素组、甘露醇组、生理盐水组和假手术对照组 ,每组又分移植后 1、4h组 ;对移植鼠血清ALT、肝损伤指数进行测定。结果 :在预防肝移植后肝脏缺血 /再灌注损伤中 ,承气方剂组和多粘菌素组优于甘露醇组和生理盐水组 ,承气方剂组又优于多粘菌素组。结论 :承气方剂能有效减轻肝移植后肝脏缺血Objective: To study the effect of Chengqi prescription in preventing hepatic ischemia/reperfusion injury after liver transplantation in rats. Methods: Rat in situ liver transplantation model was used, donor liver was preserved in Ringer′s solution for 4 hrs under 4℃, then divided randomly into Chinese medicine group (Chengqi prescription), polymyxin B group, mannitol group, normal saline group and sham operation control group, each group further subdivided into two subgroups: 1 hr group and 4 hrs group after transplantation. The serum ALT and liver injury index was determined. Results: In preventing hepatic ischemia/reperfusion injury after liver transplantation, the Chengqi prescription and polymyxin B showed more effective than that of mannitol and normal saline, and the effect of Chengqi prescription was higher than that of polymyxin B (P<0 05). Conclusion: Chengqi prescription was effective in preventing hepatic ischemia/reperfusion injury after liver transplantation in rat.

关 键 词：承气方剂 预防 大鼠 肝移植 缺血 再灌注损伤 

分 类 号：R269[医药卫生—中西医结合]