四[对-(羧基甲氧基)苯基]卟啉金属配合物(M=Zn,Cu,Ni)的π-π配合及其二丁基锡(Ⅳ)酯衍生物的抗癌活性  

Aggregation and π-π Coordination of Tetra[4-carboxymethoxyphenyl] Porphyrin Metal Complex(M=Ni, Cu, Zn) and the Vitro Antitumor Activity of Dibutyltin(Ⅳ) Tetra{[4-carboxymethoxyphenyl]}porphyrinate

作　　者：韩高义[1] 杨频[2] 

机构地区：[1]南京大学配位化学国家重点实验室,南京210093 [2]山西大学分子科学研究所,太原030006

出　　处：《高等学校化学学报》2001年第12期1993-1995,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 98710 2 0 );山西省自然科学基金 (批准号 :9910 12 )资助

摘　　要：Tetra\{\[4\|carboxymethoxyphenyl\]\}porphyrin copper(Ⅱ), nickel(Ⅱ), zinc(Ⅱ) complex and their dibutyltin(Ⅳ) ester derivatives have been synthesized and characterized. The equilibrium constants of the aggregation of the metal porphyrin and the equilibrium constant of the π\|π coordination with phenothoroline have been measured by using UV\|Vis titration method. The results show that the equilibrium constants decrease in the order of K \-\{CuP\}> K \-\{NiP\}> K \-\{ZnP\}. The vitro anti\|tumor activities of the dibutyltin(Ⅳ) metal porphyrinate has some relation with the ability of aggregation and coordination with ligand of the metal porphyrin.Tetra\{\[4\|carboxymethoxyphenyl\]\}porphyrin copper(Ⅱ), nickel(Ⅱ), zinc(Ⅱ) complex and their dibutyltin(Ⅳ) ester derivatives have been synthesized and characterized. The equilibrium constants of the aggregation of the metal porphyrin and the equilibrium constant of the π\|π coordination with phenothoroline have been measured by using UV\|Vis titration method. The results show that the equilibrium constants decrease in the order of K \-\{CuP\}> K \-\{NiP\}> K \-\{ZnP\}. The vitro anti\|tumor activities of the dibutyltin(Ⅳ) metal porphyrinate has some relation with the ability of aggregation and coordination with ligand of the metal porphyrin.

关 键 词：四[对-(羧基甲氧基)苯基]卟啉金属配合物 二丁基锡酯 体外抗癌活性 衍生物 锌 铜 镍 π-π配合 

分 类 号：R979.1[医药卫生—药品]