一步法立体专一性合成游离β-吡喃糖碳苷  

Stereospecific Synthesis of Free Hydroxyl β-C-Glycosides in One Sstep

作　　者：王文忠[1] 张佩瑛[2] 吕以仙[2] 

机构地区：[1]华北煤炭医学院药学系,唐山063000 [2]北京大学药学院化学生物学系,北京100083

出　　处：《高等学校化学学报》2001年第12期2037-2039,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 9472 0 34)资助

摘　　要：Free aldopentoses and aldohexoses reacted respectively with (EtO) 2P(O)CHNaCOAr to give the five stereospecific free hydroxyl \%β\% C glycosides in one step. The reaction take place under a mild condition. The procedures are simple and convenient. The prices of starting materials are cheap. The method can be applied universally for aldopentoses and aldohexoses. The application scope of Wittig Horner reaction has also been expanded. The synthesis of free hydroxyl \%β\% C glycosides from free aldoses directly using Witting\|Horner reaction has not been reported so far.Free aldopentoses and aldohexoses reacted respectively with (EtO) 2P(O)CHNaCOAr to give the five stereospecific free hydroxyl \%β\% C glycosides in one step. The reaction take place under a mild condition. The procedures are simple and convenient. The prices of starting materials are cheap. The method can be applied universally for aldopentoses and aldohexoses. The application scope of Wittig Horner reaction has also been expanded. The synthesis of free hydroxyl \%β\% C glycosides from free aldoses directly using Witting\|Horner reaction has not been reported so far.

关 键 词：合成 WITTIG-HORNER反应 β-吡喃糖碳苷 茂醛糖 已醛糖 

分 类 号：O629.13[理学—有机化学]