低分子肝素钙在急性心肌梗死溶栓前的应用  

Use of low molecular-weight heparin calcium prior to thrombolytic therapy for acute myocardial infarction

作　　者：高翔[1] 冯燕娴[1] 孙宝玲[1] 阳海红[2] 

机构地区：[1]安徽省蚌埠市第三人民医院心内科,233000 [2]安徽省阜阳市人民医院心内科,236000

出　　处：《蚌埠医学院学报》2001年第6期487-488,共2页Journal of Bengbu Medical College

摘　　要：目的 :探讨低分子肝素钙在急性心肌梗死溶栓治疗前应用的作用。方法 :低分子肝素钙组 ,溶栓前静脉注射低分子肝素钙 5 0 0 0u ,随即给予尿激酶 2 2 0 0 0u/kg ,加入生理盐水 10 0ml中 ,在 30min内滴完。对照组除未使用低分子肝素钙外 ,余治疗同肝素钙组。冠状动脉再通标准为同时具备 1996年 7月太原会议参考方案中间接指征的第 1、4两项。结果 :低分子肝素钙组 48例中 39例再通 ,再通率 81.2 5 % ;对照组 41例中再通 2 4例 ,再通率 5 8.5 4% ,两组血管再通率差异有显著性 (P <0 .0 5 )。结论Objective:To evaluate the role of low molecular weight heparin calcium used before thrombolytic therapy for acute myocardial infarction.Methods:Five thousamd unit low molecular weight heparin calcium was injected intravenously to the patients before thrombolytic therapy,then 22 000 u/kg urokinase dissolved in 100 ml 0.9% sodium chloride solution was instilled within 30 minutes.The controls received the same treatment except that they were not given heparin.The standard of re unobstruction for coronary artery was in accordiance with the first and fourth intems of the Reference Draft drawn up in Taiyuan Conference in July,1996.Results:Thirty nine of the 48 cases in the group using low molecular weight heparin calcium achieved re unobstruction and the cure rate was 81.25%.Only 24 of the 41 cases in the control group manifested re unobstruction and the cure rate was 58.54%.The difference was significant( P <0.05).Conclusions:It is suggested that low molecular weight heparin calcium be used before thrombolytic therapy for acute myocardial infarction.

关 键 词：心肌梗死 肝素 低分子量 血栓溶解疗法 

分 类 号：R542.220.5[医药卫生—心血管疾病]