血栓素/前列环素与小儿肾病综合征白色微血栓关系  

The relationship between TXA_2/PGⅠ_2 and white microthrombus in the children with nephrotic syndrome

作　　者：杨达胜[1] 浮纪玲 杨献云 盛凯[1] 

机构地区：[1]新乡医学院第一附属医院小儿科,卫辉453100 [2]河南省新乡县人民医院小儿科,新乡453000 [3]北京市公安医院,北京100006

出　　处：《中国中西医结合肾病杂志》2001年第11期636-637,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：河南省自然科学基金资助项目 (No .96 40 2 490 0 )

摘　　要：目的 :探讨血栓素 /前列环素 (TXA2 /PGI2 )与原发性肾病综合征 (PNS)外周微循环白色微血栓发生的关系。方法 :采用WS - 9型体表微循环观察仪检测甲皱微循环 ,根据有无白色微血栓将 71例PNS患儿分为无白色微血栓组 (1组 ,5 0例 )和有白色微血栓组 (2组 ,2 1例 )。用放免法测定两组患儿血和尿中血栓素A2 (TXA2 )和前列环素(PGI2 )代谢终产物血栓素B2 (TXB2 )及 6 -酮前列环素F1a(6 -K -PGF1a)。正常对照组 31例。结果 :2组血清TXB2 明显高于 1组和对照组 (P <0 .0 1)。 2组TXB2 /6 -K -PGF1a比值明显高于 1组 (P <0 .0 5 ) ;1组TXB2 /6 -K -PGF1a比值高于对照组 (P <0 .0 5 )。 2组尿TXB2 和TXB2 /6 -K -PGF1a比值明显高于 1组和对照组 (P <0 .0 1)。结论 :血栓素 /前列环素失衡在小儿肾病综合征白色微血栓形成和肾损伤中起重要作用。Objective:To research the relationship between TXA 2/PGI 2 and white microthrombus in primary nephrotic syndrome(PNS)patients.Methods:71 children with PNS were divided into two groups.The group 1 (n=50) was PNS without white microthrombus.The group 2 (n=21) was PNS complicated with white microthrombus.16 parameters on the situation of microvascular morphology,blood flowing and perimicrovessels of the microcirculation of the 4 th fingernail of the hand,esp.The evidence for the existence by means of WS-9 surface microcirculation detector and microscope-equipment TV.The levers of TXB 2/6-K-PGF 1a was determined by radioimmunoassay.31 health children were chosen as control group.Results:The levels of serum TXB 2 were significantly higher in group 2 than that of group 1 and control group(P< 0.01 ),The ratio of TXB 2/6-K-PGF 1a were significantly higher in group 2 than that of group 1 (P< 0.05 );The ratio of TXB 2/6-K-PGF 1a were significantly higher in group 1 than that of control group(P< 0.05 ),The levels of urine TXB 2 and the ratio of TXB 2/6-K-PGF 1a were significantly higher in group 2 than that of group 1 and control group(P< 0.01 ).Conclusion:In children with PNS,TXA 2/PGⅠ 2 plays an important role in the pathogenesis of white microthrombus and renal injury.

关 键 词：肾病综合征 血栓素 前列环素 白色微血栓 小儿 

分 类 号：R726.91[医药卫生—儿科]