丙型肝炎病毒血清学分型应用的可行性研究  

Study on applicability of hepatitis C virus serotyping

作　　者：张天泰[1] 张庶民[2] 高评[1] 谢晨[1] 陈青锋[1] 庄辉[3] 

机构地区：[1]兰州医学院附属一院,730000 [2]中国药品生物制品检定所 [3]北京医科大学微生物系

出　　处：《中华实验和临床病毒学杂志》2001年第4期355-356,共2页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　探讨丙型肝炎病毒血清学分型的可行性。方法　应用EIA法对兰州地区 148例抗 HCV阳性者进行血清学分型。结果　血清学方法的分型率为 5 6 0 8% (83 148) ,其中血清 1型占5 0 6 0 % (4 2 83) ,血清 2型占 43 37% (36 83) ,1+2混合型占 6 0 3% (5 83)。对其中 70例HCVRNA阳性血清的基因型与血清型结果进行比较 ,二者完全相符。Objective To explore the applicability of HCV serotyping.Methods Enzyme immunoassay (EIA) was used to detect the serotypes of 148 patients with viral hepatitis C.Results 56\^08%(83/148) patients were sero typed,of whom 50\^06%(42/83) were identified to be serotype 1,43\^37%(36/83) serotype 2,and 6\^03%(5/83)mixed serotype 1 and 2.The sera from 70 HCV RNA\|postitive patients out of the 83 ones who were successfully serotyped were detected for genotyping.The results were completely consistent between serotyping and genotyping.Conclusion Serotyping of HCV has its clinical applicable value.

关 键 词：丙型肝炎 丙型肝炎病毒 血清分型 可行性研究 

分 类 号：R373[医药卫生—病原生物学]