1995至2000年北京地区散发性急性肝炎患者肝炎病毒抗体的检测与分析  

Detection of anti-HAV,anti-HBV,anti-HCV and anti-HEV antibodies in the patients with sporadic acute hepatitis in Beijing during 1995—2000

作　　者：江永珍[1] 鲁健[1] 赵洪兰[1] 张文英[1] 廖胜东[2] 孟庆玲[1] 汪媛[1] 詹美云[1] 

机构地区：[1]中国预防医学科学院病毒学研究所肝炎病毒研究室,北京100052 [2]首都医科大学天坛医院消化内科

出　　处：《中华实验和临床病毒学杂志》2001年第4期360-362,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　了解北京市地区散发性肝炎患者甲型、乙型、丙型和戊型肝炎病毒感染型别分布及重叠感染。方法　用EIA法检测 1995年 2月至 2 0 0 0年 12月北京地区散发性急性肝炎患者抗 HAVIgM、HBsAg 抗 HBcIgM、抗 HCVIgM IgG和抗 HEVIgM IgG。结果　 2 14例散发性急性肝炎患者血清 ,抗甲、乙、丙和戊型肝炎病毒IgM总阳性数 15 5例 ,总阳性率为 72 4%。在 15 5例急性病毒性肝炎中 ,甲型肝炎 45例 ,乙型肝炎 2 8例 ,丙型肝炎 6例 ,戊型肝炎 76例。有 9名患者检出 2种肝炎病毒抗原或抗体阳性 ,其中在 3名肝硬化患者和 2名静脉吸毒者同时检测到HBV和HCV抗原或抗体 ,1例HB sAg阳性者检测到抗 HAVIgM ,3例 HCVIgG阳性者中分别检测到 2例抗 HAVIgM和 1例抗 HEVIgM。肝炎病毒重叠感染的 9名患者年龄在 31岁至 49岁之间。结论　北京地区散发性急性肝炎78%是由消化道传染的甲戊型肝炎病毒引起 ,戊型肝炎在四种肝炎中位居首位 ,其次为甲型肝炎、乙型肝炎和丙型肝炎。肝炎病毒重叠感染多见乙、丙型肝炎病毒合并感染或慢性乙、丙型肝炎患者合并甲型或戊型肝炎病毒感染。Objective To investigate distribution of acute hepatitis A,hepatitis B,hepatitis C and hepatitis E in Beijing area.Methods Enzyme immunoassay (EIA) was used for detection of anti\|HAV immunoglobulin M (IgM),HBsAg/anti\|HBc IgM,anti HCV IgM/IgG and anti\|HEV IgM/IgG.The samples were collected from the patients with sporadic heaptitis in Beijing city between 1995 and 2000.Results The total positive rate of IgM antibodies to the four hepatitis\|viruses was 72.4% (155) among 214 patients with sporadic acute hepatitis; the positive rates for the 4 viruses were 29%(45) for anti\|HAV,18.1%(28) for anti\|HBc,3.9%(6) for anti\|HCV and 49%(76) for anti\|HEV among 155 patients with acute viral hepatitis.Nine patients were coinfected with two hepatitis viruses.Conclusion 78% of patients with sporadic acute hepatitis were caused by enterically transmitted hepatitis viruses (A and E) in Beijing between 1995 and 2000,Hepatitis E had the highest rate.Coinfection with two hepatitis virus was found in the patient with intravenous drug abusers and cirrhosis or acute hepatitis.

关 键 词：散发性肝炎 肝炎病毒 病毒抗体 IGM IGG 

分 类 号：R446.62[医药卫生—诊断学]