二苯甲撑二异氰酸酯对男工性激素水平的影响  

Effects of exposure to diphenyl methane diisocyanate on serum sexual hormone in male workers

作　　者：杜晨阳[1] 李序梅[1] 朱宝立[2] 曾晓燕[2] 殷向明[3] 季久林[3] 

机构地区：[1]江苏省卫生监督所,江苏南京210009 [2]江苏省疾病控制中心,江苏南京210009 [3]江苏油田防疫站,225261

出　　处：《中国工业医学杂志》2001年第6期345-347,共3页Chinese Journal of Industrial Medicine

摘　　要：目的　探讨二苯甲撑二异氰酸酯 (MDI)对作业男工体内性激素水平的影响。方法　对某化工厂 84名接触MDI的男工和 96名对照男工血清睾酮 (T)、卵泡刺激素 (FSH)和黄体生成素 (LH)水平进行检测和比较。结果　MDI作业男工血清T水平显著低于对照组 (P <0 0 1) ;FSH及LH水平显著高于对照组 (P <0 0 1) ;高浓度接触组男工血清T显著低于中浓度组和低浓度组 (P <0 0 1) ,而LH及FSH却显著高于中浓度组和低浓度组 (P <0 0 1) ;MDI作业男工性功能与对照组相比显著减退 (P <0 0 1) ;吸烟饮酒可导致血清T水平显著低于未吸烟饮酒组 (P <0 0 1) ,而LH及FSH与未吸烟饮酒组无明显差异 (P >0 0 5 ) ,且MDI与吸烟饮酒三者存在协同作用的关系。结论　MDI具有一定的生殖毒性。Objective To explore the effects of exposure to diphenyl methane diisocyanate(MDI)on serum levels of sexual hormones in male workers.Methods Serum levels of testosterone(T),follicle stimulating hormone(FSH)and leutinizing hormone(LH)were determined in 84 workers exposed to MDI and 96 controls for comparison.Results Serum level of T was significantly lower in the exposed workers than in the controls(P<0 01),and serum levels of FSH and LH were significantly higher in the exposed workers than in the controls(P<0 01).Serum level of T in the high dose exposed group was significantly lower than those in the medium and low dose exposed ones,but those of LH and FSH in the high dose exposed group were significantly higher than those in the medium and low dose exposed ones.Sexual function significantly decreased in the workers exposed to DMI than in the controls(P<0 01).Smoking and alcohol drinking could cause decrease in serum level of T,as compared with non smoking and non drinking groups(P<0 05),but no difference in serum FSH and LH whether smoking and drinking or non smoking and non drinking was found(P>0 05).Exposure to MDI had synergism with smoking and alcohol drinking.Conclusions MDI could cause certain damage in reproductive function.

关 键 词：二苯甲撑二异氰酸酯 男性性功能 性激素 

分 类 号：R994.3[医药卫生—毒理学]