2型糖尿病危险因素的病例对照研究  

A case-control study of risk factors for type 2 diabetes mellitus

作　　者：马骏[1] 王建华[2] 王正伦[2] 刘新民[2] 

机构地区：[1]天津医科大学公共卫生学院卫生统计学教研室,300070 [2]天津医科大学公共卫生学院流行病学教研室,300070

出　　处：《中华流行病学杂志》2001年第5期365-367,共3页Chinese Journal of Epidemiology

摘　　要：目的　研究胰岛素抵抗等因素与 2型糖尿病的关系。方法　对根据WHO诊断标准确诊的 10 2例 2型糖尿病病人进行 1∶1配比病例对照研究 ,采用条件logistic回归分析方法处理资料。结果　单因素分析结果显示胰岛素抵抗与 2型糖尿病发病有关 ,OR值为 1.5 30 (95 %CI:1.2 34～1.896 ) ,用可能起混杂作用的多重因素调整后 ,这种关系依然存在。结论　胰岛素抵抗是 2型糖尿病病因 ,并且其作用相对独立。Objective The prevalence of type 2 diabetes mellitus is increasing so to investigate the relation between insulin resistance and development of type 2 diabetes mellitus. Methods A 1∶1 pair matched case control study was conducted with diagnostic criteria recommended by WHO. Controls matched with cases by age, sex, race and resident place. Information on demographic, history of disease, life style were obtained through questionnaire. Variables including fasting blood glucose (FBG), fasting blood insulin (FBI), total cholesterol (TC), triglyceride (TG), waist to hip ratio (WHR),waist to thigh ratio (WTR) were measured for every subject. Conditional logistics regression was used for data analysis. Results The results showed that insulin resistance, history of hypertension and waist to hip ratio were associated with type 2 diabetes mellitus. The values of OR were 1.530 (95% CI : 1.234 - 1.896 ), 4.833 (95% CI : 1.996 - 11.703 ), 21.996 (95% CI : 5.461 - 88.593 ), respectively. Conclusion Insulin resistance was risk factor causing type 2 diabetes mellitus, independent of other risk factors.

关 键 词：2型糖尿病 胰岛素抵抗 危险因素 病例对照研究 

分 类 号：R587.1[医药卫生—内分泌]