ATP敏感性钾通道与心肌低氧损伤  

ATP-sensitive Potassium Channel and Myocardial Hypoxia Injury

作　　者：祝芬[1] 马季骅[1] 

机构地区：[1]武汉科技大学医学院,湖北武汉430080

出　　处：《武汉科技大学学报》2001年第4期417-420,共4页Journal of Wuhan University of Science and Technology

摘　　要：ATP敏感性钾通道是一种受细胞内ATP浓度 ,NDPs ,KCOs ,SUs等多种因素调节启闭的钾通道。在低氧条件下 ,ATP敏感性钾通道被激活 ,引起动作电位时程缩短和细胞外钾离子蓄积 ,减少钙离子内流 ,对心肌有一定的保护作用 ;但过度的钾离子外流 ,对心肌则有损害 ,甚至诱发心律失常。提示 :ATP敏感性钾通道的开放 ,可能是低氧引起心肌损伤的一种内源性机制。ATP sensitive potassium channel(K ATP ) is modulated by many factors such as ATP concentration,NDPs,KCOs,SUs, etc. The activation of the ATP sensitive potassium channel during myocardial hypoxia leads to potassium efflux, action potential duration shortening and reduction of calcium influx in the cells. It is assumed that K ATP might be a reason for cardioprotective effects. But the excessive accumulation of extracellular potassium induces the formation of ventricular arrhythmia.This study indicates that the ATP sensitive potasstium channel's opening might be an intrinsic mechanism in myocardial hypoxia injury.

关 键 词：ATP敏感性钾通道 心肌 低氧损伤 钾离子外流 KATP 心律失常 

分 类 号：R331.3[医药卫生—人体生理学] R541.7[医药卫生—基础医学]