渗出性心包炎患者血浆和心包液中AM浓度的测定  

Measurement of Plasma and Pericardial Fluid Adrenomedullin Concentrations in Patients with Pericarditis with Effusion

作　　者：杨玉雯[1] 张新路[2] 

机构地区：[1]皖南医学院弋矶山医院内科,241001 [2]皖南医学院弋矶山医院核医学科,241001

出　　处：《放射免疫学杂志》2001年第5期263-264,共2页Journal of Radioimmanology

摘　　要：目的 :探讨肾上腺髓质素 (AM)在大量心包积液时对血循环的调节作用。方法 :用放射免疫分析法分别测定了渗出性心包炎伴大量积液患者治疗前后血浆及心包液中AM的含量。结果 :大量渗出性心包积液患者血浆AM值在治疗后较治疗前明显降低 (P <0 .0 1)。与正常组比无显著差异 (P >0 .0 5 )。渗出性心包积液患者心包液中AM值在治愈后较治疗前显著降低 (P <0 .0 1)。结论Objective To detect the adjustive role played by adrenomedullin (AM) on circulation in patients with massive pericardial effusion. Method Plasma and pericardial fluid AM levels were measured by radioimmunoassay in 35 patients with massive pericarditil effusion before and after treatment and in 30 normal subjects (plasma only) as controls. Results Pericardial fluid and plasma AM levels in the patients before therapy were significantly higher than those after therapy ( P <0.01). Plasma AM levels in patients after therapy were about the same as those in normal subjects ( P >0.05). Conclusion AM synthesis and secretion were greatly enhanced by myocardium and other tissue cells in patients, which could regulate blood pressure with coronary vessels dilatation to maintain oxygen supply.

关 键 词：渗出性心包炎 肾上腺髓质素 血浆 心包液 浓度测定 

分 类 号：R542.11[医药卫生—心血管疾病]