皮下注射胰岛素对冠心病合并糖尿病^(18)F-FDG心肌显像的影响  

Effect of subcutaneous injection of insulin on ^(18)F-FDG myocardial imaging in diabetics

作　　者：田月琴[1] 史蓉芳[1] 郭风[1] 魏红星[1] 吴清文[1] 刘秀杰[1] 

机构地区：[1]中国医学科学院,中国协和医科大学阜外心血管病医院核医学科,北京100037

出　　处：《中华核医学杂志》2001年第5期284-285,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　评价皮下注射胰岛素对冠心病合并糖尿病患者18F 脱氧葡萄糖 (FDG)心肌代谢显像的影响。方法　冠心病合并糖尿病患者 5 7例 [男 5 1例 ,女 6例 ,年龄 (6 0± 8)岁 ],行18F FDGPET和SPECT超高能准直器99Tcm 甲氧基异丁基异腈 (MIBI) / 18F FDG双核素同时采集心肌显像。显像前测定血糖 ,根据不同血糖浓度 ,皮下注射不同剂量胰岛素。结果　 5 7例冠心病合并糖尿病患者的血糖 (x)变化与胰岛素剂量 (y)间呈直线相关 ,y =- 5 .4+1.2x (r=0 .8172 )。采用上述方法后 5 7例患者中 5 2例心肌显像良好 ,成功率 91%。结论　皮下注射胰岛素简单、安全、实用 ,可改善糖尿病患者心肌18FObjective This study was performed to evaluate the effect of subcutaneous injection of insulin on 18 F fluorodoexyglucose (FDG) myocardial imaging in patients with diabetes mellitus. Methods Fifty seven patients with coronary artery disease complicated with diabetes mellitus [mean age (60±8) years] underwent 18 F FDG PET and dual isotope simultaneous acquisition SPECT with 99 Tc m MIBI/ 18 F FDG. Thirty minutes before FDG injection, blood glucose was measured with an automatic glucose analyzer and insulin was subcutaneously used,the dose was adjusted according to the level of blood glucose. Results Regression analysis showed that the insulin was positively associated with blood glucose. The linear regression analysis showed that the correlation between dose of insulin ( y ) and blood glucose ( x ) was good, r =0.817 2;the linear regression equation was y =-5.4+1.2 x. 52 of 57 images were of good quality with 91% success rate. Conclusion Subcutaneous injection of insulin is an effective and simple method for obtaining cardiac FDG images of good quality in patients with diabetes mellitus.

关 键 词：糖尿病 胰岛素 冠心病 SPECT ^18F-FDG 心肌显像 

分 类 号：R541.4[医药卫生—心血管疾病]