肿瘤核素反义显像技术的研究现状与展望  

Current researches and prospective of radiolabeled antisense imaging in tumor

作　　者：秦光明[1] 

机构地区：[1]华中科技大学同济医学院协和医院核医学科,湖北武汉430022

出　　处：《国外医学（放射医学核医学分册）》2001年第5期213-216,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

基　　金：湖北省科委课题基金

摘　　要：反义显像具有不引起免疫反应、探针分子小、易进入瘤组织等优点 ,具有广阔的应用前景 ,但靶序列的选择、理想寡核苷酸的确定等仍是现阶段制约其发展的重要因素。因此 ,将反义显像引入体内研究还有很多问题需要解决 ,包括如何提高探针的体内稳定性、增加靶细胞的选择性摄取和滞留。Radiolabeled antisense imaging may be defined as the detection of diseases through the administration of radiolabeled antisense oligonucleotide designed to bind in a sequence specific manner to the machinery of translation or transcription. No immunogenity, low molecular weight of probes and easily penetrating the tumor cells are some of it's good aspects.Despite its good prospective, factors as selection of targeted serial, identification of ideal oligonucleotides are still roadblocks in developing antisense imaging. Many problems must be solved before in vivo application of antisense imaging, among those including in vivo stability, specific absorption and retention by targeted cells, nonspecific serum binding, and so on.

关 键 词：反义显像 肿瘤诊断 寡聚核苷酸 癌基因 放射性核素 

分 类 号：R817[医药卫生—影像医学与核医学]