二色桌片参的化学成分的研究(V)二色桌片参糖蛋白抗肿瘤活性的研究  

Study on the anti tumor activity of glycoproteins GPMI-Ⅰ and GPMI-Ⅱ extracted from sea cucuber Mensamaria intercedens

作　　者：陈粤[1] 苏文金[1] 吴萍如 方金瑞 

机构地区：[1]厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室 [2]福建海洋研究所,厦门361012

出　　处：《中国海洋药物》2001年第5期1-3,共3页Chinese Journal of Marine Drugs

摘　　要：本文探讨二色桌片参糖蛋白 GPMI- 和 GPMI- 对小鼠移植性肿瘤 S180 的抑制作用以及对荷瘤小鼠肝脾等器官重量的影响。实验结果显示 ,经蛋白酶水解后的糖蛋白 GPMI- 在剂量 2 0μg· g-1时小鼠肉瘤S180 有较显著的抑制作用 (P<0 .0 5 ) ,抑瘤率达 4 8.8%。同时发现 ,GPMI- 在 30μg· g-1剂量下可显著增加荷瘤小鼠的脾指数 (P<0 .0 5 ) ,GPMI- 在 4 0 μg· g-1剂量下能够显著降低荷瘤小鼠肝指数 (P<0 .0 5 )。In this study,two kinds of glycoproteins GPMI Ⅰ and GPMI Ⅱ were extractyed from sea cucuber Mensamaria intercedens.Their anti tumor activity to mice implanted tumor S 180 were evaluated in vivo by anti tumor assay.The results indicated that GPMI Ⅱ could significantly inhibit the growth of S 180 cells implanted subcutaneously in mice ( P <0.05) at the dose of 20μg·g -1 per day×10 with no sign of toxicity.The ratio of tumor inhibition is 48.8% in S 180 mice.The effects appear to be dose related.On the other hand, GPMI Ⅰ increases the weight of spleen of mice with S 180 cells at the dose of 30μg·g -1 per day×10 . GPMI Ⅱ decreases the weight of liver of mice with S 180 cells at the dose of 40μg·g -1 per day×10 .

关 键 词：二色桌片参 糖蛋白 肉瘤S180 抑瘤作用 

分 类 号：R931.74[医药卫生—生药学]