麻黄碱预防硬膜外加异丙酚全麻诱导时血流动力学变化  

Prophylactic Ephedrine Attenuates the Hemodynamic Response to Propofol Induction Plus Epidural Anesthesia

作　　者：庄小凤[1] 薛张纲[1] 蒋豪[1] 

机构地区：[1]复旦大学附属中山医院麻醉科,上海200032

出　　处：《中国临床医学》2001年第5期545-546,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :观察预注麻黄碱是否可以消除或缓解异丙酚加硬膜外阻滞时的低血压。方法 :6 0例ASA 1～ 2级的肝脏手术病人分成 3组 ,组 1为对照组 ,组 2和组 3在异丙酚全麻诱导前分别静脉注射麻黄碱 0 .1和 0 .2mg/kg ,观察静脉注射异丙酚后血压和心率的变化。结果 :与对照组相比 ,全麻诱导前预注麻黄碱可明显减轻血压下降的程度 ,且麻黄碱 0 .2mg/kg比0 .1mg/kg效果更佳。但并不能完全避免异丙酚诱导时的血压下降。结论 :联合麻醉诱导前 ,可以常规静脉注射麻黄碱 0 .1～ 0 .Objective: To observe the effect of prophylactic administration of ephedrine against the hypotensive effect of propofol plus epidural anesthesia. Methods: Sixty patients who underwent hepatic surgery with ASAⅠ-Ⅱwere randomly allocated to one to three groups of 20 each to receive either normal saline, ephedrine 0.1mg/kg, or ephedrine 0.2mg/kg intravenously before the induction of anesthesia with propofol. The change of blood pressure and heart rate was observed. Result: The decrease in blood pressure and heart rate was significantly less in each of the ephedrine groups, furthermore, the decrease was less in the group of ephedrine 0.2mg/kg. But the prophylactic injection of ephedrine did not completely abolish the decrease in blood pressure associated with induction of anesthesia with propofol plus epidural anesthesia. Conclusion: Prophylactic ephedrine 0.1-0.2mg/kg routinely before induction of propofol plus epidural anesthesia can effectively ameliorate the degree of hypotension.

关 键 词：异丙酚 麻黄素 硬膜外麻醉 全麻诱导 

分 类 号：R614.2[医药卫生—麻醉学] R614.42[医药卫生—外科学]