妊娠高血压综合征红细胞膜ATP酶活性的变化  

Changes of erythrocyte membrane ATPase activity in patients with pregnancy-induced hypertension

作　　者：张凌云[1] 何援利[1] 张为远[2] 陈炜[1] 杨芳[1] 杨建萍 

机构地区：[1]第一军医大学珠江医院妇产科,广东广州510282 [2]白求恩医科大学第二临床医院妇产科,吉林长春130021 [3]广东省大埔县人民医院妇产科,广东大埔514200

出　　处：《第一军医大学学报》2001年第10期763-765,共3页Journal of First Military Medical University

摘　　要：目的探讨妊娠高血压综合征(妊高征)患者红细胞膜ATP酶活性的变化。方法采用生化方法测定25例妊高征患者和27例正常孕晚期妇女红细胞膜ATP酶活性以及膜胆固醇和甘油三脂的含量。结果妊高征患者产前Na+,K+-ATP酶和Ca2+-ATP酶活性显著低于对照组,胆固醇含量明显高于对照组,而甘油三脂的含量两组间未见明显差异。妊高征患者产前红细胞膜胆固醇含量与膜Na+,K+-ATP酶和Ca2+-ATP酶活性呈明显的负相关。结论妊高征患者ATP酶活性降低是其依赖的脂质微环境发生改变的结果。Objective To evaluatethechangesof ATPaseactivityon theerythrocytemembranein patientswithpregnancy-inducedhypertension(PIH).Methods Twenty-fivepatientswithPIHand27healthywomenin theirlatepregnancywere includedin thisstudy.ErythrocytemembraneATPaseactivitywas measuredby biochemicalmethod,andcholesteroland triglyceridecontentby cholesteroloxidasemethodandglycerophosphoricacidoxidasemethod,respectively.Thecorrelation of thecholesterolcontentto ATPaseactivitywas observed.Result Theactivityof Na + ,K + -ATPaseandCa 2+ -ATPasewas significantlylower,whilecholesterolcontentsignificantlyhigherin PIHpatientsthanin the healthypregnantwomen.Triglyceridecontentshowedno differencebetweenPIHand controlgroups.Negativecorrelationof cholesterolto Na + ,K + -ATPaseandCa 2+ -ATPaseactivitywas observed.Conclusion Thedecreaseof ATPaseactivitywas primarilydueto the alterationof lipidcomponentinthecellmembrane.

关 键 词：妊娠高血压 腺苷三磷酸酶 胆固醇 甘油三脂类 

分 类 号：R714.246[医药卫生—妇产科学]