新生儿出血症的临床及凝血因子相关的研究  

A STUDY OF CLINCIAL AND FACTORS OF THROMBIN IN HEMORRHAGIC DISEASE OF THE NEWBORN

作　　者：张纪平[1] 蔡宝珍[1] 金敏荣[1] 韩玉兰[1] 邱艳[1] 

机构地区：[1]武汉儿童医院,430016

出　　处：《中国小儿血液》2001年第5期200-202,共3页China Child Blood

摘　　要：为研究新生儿出血症的凝血因子促凝活性与临床出血的关系。运用AcL2 0 0型全自动凝血仪及库尔特试剂对 48例新生儿出血症及 2 5例无临床出血的正常新生儿进行凝血因子检测。结果显示 ,48例患儿以消化道、颅内及皮肤粘膜出血为主 ,出血部位越多 ,症状越重。患儿各种凝血因子活性均减低与正常对照相比有显著性差异(P <0 0 1 )。凝血因子减少在 4个以上占 58 3 % ,多以II、VII、IX、X及XI、XII的复合缺乏 ,9例是II、V、XI、XII单个因子缺乏。因此 :1 新生儿出血症是凝血因子促凝活性减低 ,个数减少的出血性疾病。 2 发病原因是与维生素K缺乏、肝功发展不全及其他相关因素有关 ,应加强对出生新生儿的防治。 3 XII因子活性减低对启动血管内凝血有重要意义 ,但不减低者与组织因子途径有关 。To undertaken the relation both clinical hemorrhage and vigour prothrombinogenic in hemorrhagic disease of the newborn, using factor of thrombin in 48 cases of hemorrhagic disease of newborn and 25 normal control group were examined by automatic statement of thrombokinesis: TYPE ACL-200. Result showed severe symptom is positive correlation more bleeding in 48 patients including gastroenteric, et al than in normal control group (P<0 01). More than four factors decreased in 58 3% of the patients, except show mono factor(Ⅱ Ⅴ Ⅺ Ⅻ) absence in 9 patient. Therefore, 1. The hemorrhagic disease of the newborn correlation with vigour liver and number decreased of thrombin factor. 2. There are lots of causes for hemorrhageic disease of the newborn, VitK, absence, abnormal function of liver and others factor, reinforce precaution and treatment in newbborn when was born. 3. Vigour of factor XII decreased is important meaning at course of thrombokinesis, but request still undertaken.

关 键 词：新生儿出血症 凝血因子 瀑布学说 

分 类 号：R722.15[医药卫生—儿科]