EEG与SEP对糖尿病大鼠局灶性脑缺血损伤程度评价  

Evaluation of EEG and SEP on the extent of brain damage following focal ischemia/reperfusion in diabetic rats

作　　者：李广仁[1] 王桂侠[2] 郭晖[2] 张晓宏 李玲[4] 王绍[5] 

机构地区：[1]吉林大学第一医院神经科,吉林长春130021 [2]吉林大学第一医院内分泌科,吉林长春130021 [3]吉林省医院电诊科,吉林长春130021 [4]前郭县中医院内科,吉林前郭131100 [5]吉林大学基础医学院,吉林长春130021

出　　处：《中风与神经疾病杂志》2001年第5期273-275,共3页Journal of Apoplexy and Nervous Diseases

基　　金：吉林省科委资助项目 (吉科合字第 970 55 8-3号 )

摘　　要：目的　探讨脑电图 ( EEG)、体感诱发电位 ( SEP)在评价局灶脑缺血再灌注脑损伤中的意义 ,以及糖尿病状态对缺血再灌注脑损伤的影响。方法　在糖尿病状态下制备中脑动脉阻塞 ( MCAO)模型 ,之后在缺血再灌不同时间记录 EEG、SEP变化 ,结合组织病理进行损伤程度评价。结果　对照组和糖尿病组在 MCAO早期即出现脑电波消失 ,SEP潜伏期延长 ,波幅降低 ,再灌后有一定恢复。但是糖尿病组损伤重 ,恢复慢。组织学呈现糖尿病组梗死面积增大。结论　 MCAO模型稳定可靠 ,重复性好。EEG、SEP是评价缺血性脑损伤的敏感指标。同时说明了糖尿病组动物明显加重缺血性脑损伤。Objective To find out the meaning of EEG,SEP on evaluating the extent of brain damage following focal cerebral ischemia/reperfusion and the influence of diabetes millitus on brain injury. Methods MCAO model was made in diabetes millitus and control. And then EEG,SEP were observed in different time of ischemia/ reperfusion to evaluate the extent of brain damage combined with pathology. Results In the early of MCAO,we found that brain damage wave vanished,latency period of SEP lengthened and ampulitude went down. These changes were recovered at the different extent after reperfusion. But in diabetic group,the damage was more serious,recovered slowly and infarction enlarged in histopathology. Conclusion MCAO model is reliated,reproducible and EEG,SEP are valuable,sensitive indexes which evaluated the extent of ischemic cerebral lesions. At the same time,these results demonstrate that DM exacerbated ischemic cerebral lesion obviosly.

关 键 词：脑电图 体感诱发电位 中脑动脉阻塞 糖尿病 脑缺血 

分 类 号：R587.2[医药卫生—内分泌] R743.31[医药卫生—内科学]