硝苯地平对溴氰菊酯中毒豚鼠心血管毒性的拮抗作用  

The antagonistic effect of nifedipine on cardiovascular toxicity induced by deltamethrin in guinea pigs

作　　者：胡云平[1] 周志俊[1] 邬红梅[1] 薛寿征[1] 

机构地区：[1]复旦大学公共卫生学院劳动卫生教研室,上海200032

出　　处：《中华劳动卫生职业病杂志》2001年第4期271-273,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金资助项目 ( 395 70 62 4)

摘　　要：目的　探讨钙离子通道阻滞剂———硝苯地平对溴氰菊酯 (DM)心血管毒性的拮抗作用。方法　应用生理多导记录仪观察DM染毒及硝苯地平给药后豚鼠 2h内心血管功能的变化。结果　豚鼠一次性腹腔注射DM 2 5mg/kg,其收缩压、舒张压和心肌最大收缩速率 (dp/dt+max)值分别在15、90和 3 0min后明显升高 ,与染毒前即刻 ( 0min)相比差异有显著性 (P <0 .0 5 ) ;中毒豚鼠心电图表现为 :( 1)心率减慢 ,3 0min后降至平台期 ;( 2 )在观察时间内QRS间期持续性延长 ;( 3 )QT比值 (QTr)增大 ,15min后增至平台期 ;( 4 )心律失常发生率为 5 0 %,主要表现为房室传导阻滞和室性早搏。以硝苯地平治疗后 ,中毒豚鼠的上述心血管功能指标与染毒前即刻相比未见明显改变。结论　硝苯地平对DM中毒豚鼠的心血管毒性具有拮抗作用。Objective Toexploretheantagonisticeffectofcalciumchannelblocker,nifedipine ,oncardio vasculartoxicityinducedbydeltamethrin .Methods Thecardiovascularfunctionsofguineapigsintoxicatedby deltamethrinandtreatedwithnifedipinewereobservedbyphysiologicalpolygraphintwohours.Results Thesig nificantincreaseofsystolicanddiastolicbloodpressureandthemaximumvelocityofmyocardialcontraction (dp/dt+max)werefoundinguineapigintoxicatedbyasingledoseof 2 5mg/kgdeltamethrin(i.p)after 15 ,90and 3 0minutes,respectively,ascomparedwiththoseinaninstantbeforeintoxication( 0min ,P <0 .0 5 ) .Afteranalyzing therecordsofelectrocardiogram ,thefollowingresultswerefoundintheintoxicatedguineapigs :( 1)Heartratede creasedwithastablestageafter 3 0min .( 2 )QRSintervalwascontinuallyprolongedin 2h .( 3 )QTratio(QTr)in creasedwithastablestageafter 15min .( 4 )Theincidenceofarrhythmiaincludingablockoftransmissionbetween atriumandventricleandearlyventricularbeatingwas 5 0 %.Theseindicatorsofcardiovascularfunctionwerenot significantlychangedaftertreatmentwithnifedipineduringtheobservation ,ascomparedwiththosebeforeintoxica tion(P >0 .0 5 ) .Conclusion Nifedipinehadtheantagonisticeffectonthecardiovasculartoxicityinducedby deltamethrininguineapig.

关 键 词：溴氰菊酯 硝苯地平 心血管毒性 拮抗作用 农药中毒 治疗 

分 类 号：R99[医药卫生—毒理学]