盐酸氨溴索与激素联合使用预防新生儿肺透明膜病  

Ambroxol and Corticosteroid Usage in the Prevention of Neonatal Pulmonary Hyaline Membrane Disease

作　　者：唐海婷[1] 侍庆[1] 章蕾[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《实用妇产科杂志》2001年第6期336-337,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :研究在应用肾上腺糖皮质激素的基础上加用盐酸氨溴索 (沐舒坦 )预防新生儿肺透明膜病的效果。方法 :将 1999年 1月至 2 0 0 1年 6月我院出生的早产儿分为 3组 :实验 1组 :激素加产前用沐舒坦组 ;实验 2组 :激素加产前或产后用沐舒坦组 ;对照组 ;单用激素组。比较 3组新生儿肺透明膜病 (HMD)的发生率。结果 :实验 1组、2组 HMD的发病率均为 0 % ,对照组为 16 .6 7% ,高于两组实验组 ,统计学差异有显著意义 (P<0 .0 5 )。结论 :1产前在使用激素的基础上加用沐舒坦可预防 HMD的发生 ,疗效优于单用激素预防。 2从总体而言 ,在母亲产前使用激素的基础上 ,不论是采用产前孕母加用沐舒坦 ,还是产后新生儿用沐舒坦 ,均可有效降低 HMD的发生率 。Objectives:To study the effects of ambroxol on prevention of premature babies with pulmonary hyaline membrane disease(HMD)with prenatal corticosteroids.Method:Premature neonates with gastational age 28～36 weeks were duvided into three groups,T.e.①group 1:use Ambroxol before delivery.②group 2:use Ambroxol before or after delivery.③a control group:only give corticosteroids before or after delivery.To evaluate the three groupsoccurrence rate of HMD.Results:The occurrence rate of HMD in group 1 and 2 are both 0%.The control grouprate is 16.67%.The rate of group 1 and 2 are lower than the control group,there was significant difference( P <0.05).Conclusions:Definite effect can be received by applying ambroxol to prevent premature infant HMD before delivery on the basic of corticosteriods.

关 键 词：早产儿 肺透明膜病 盐酸氨溴素 激素 预防 新生儿 

分 类 号：R722.12[医药卫生—儿科]