甘氨酸受体的研究进展  

Inhibitory Glycine Receptor

作　　者：李萍[1] 徐祥敏[1] 杨雄里[2] 

机构地区：[1]中国科学院上海生理研究所,上海200031 [2]复旦大学神经生物学研究所,上海200433

出　　处：《生物化学与生物物理进展》2001年第5期609-614,共6页Progress In Biochemistry and Biophysics

基　　金：国家"973"计划资助项目 (G19990 5 40 0 0 )~~

摘　　要：甘氨酸受体 (GlyR)是中枢神经系统中一种重要的抑制性受体 .GlyR是氯离子 (Cl-)选择性通道蛋白 ,属于配体门控离子通道超家族的一员 .天然GlyR是由α和β亚基组装而成的五聚体 .介绍了近年来有关GlyR的结构、功能、药理特性研究的重要进展 ,并结合本实验室工作 。Inhibition at central synapses is majorly mediated by glycine and gamma -aminobutyric acid (GABA). Glycine acts by binding to a specific receptor and opening an intrinsic chloride channel. The inhibitory glycine receptor (GlyR) widely expressed in many regions of the central nervous system is a member of the ligand-gated ion channel receptor superfamily. GlyR consists of five similar subunits (3 alpha, 2 beta) arranged to form a ring around a central pore. Since the glycine-binding site is distant from the pore, long-range allosteric interactions are needed to couple agonist binding to channel gating. Recent advances in understanding the structure, physiological and pharmacological characteristics of GlyR are reviewed and modulation of GlyR and possible underlying mechanisms are discussed, in special reference to the recent work in our laboratory.

关 键 词：甘氨酸 甘氨酸受体 配体门控离子通道 抑制性神经递质 视网膜 

分 类 号：R338[医药卫生—人体生理学] Q593.2[医药卫生—基础医学]