氧化低密度脂蛋白对兔脑动脉内皮依赖的舒张的影响  

Effects of Oxidized Low-density Lipoprotein on Endothelium-dependent Relaxation in Carotid and Basilar Artery of Rabbits

作　　者：周卫东[1] 王拥军[1] 魏岗之[1] 赵凤丽[1] 周茗[1] 刘璐[1] 马金城[2] 李林[2] 

机构地区：[1]首都医科大学宣武医院神经内科,100053 [2]首都医科大学宣武医院药理研究室,100053

出　　处：《中国临床神经科学》2001年第4期334-337,共4页Chinese Journal of Clinical Neurosciences

基　　金：北京市科委科技新星资助项目(855870400)

摘　　要：目的:比较氧化低密度脂蛋白(ｏｘ－ＬＤＬ)对兔离体颈动脉和基底动脉的内皮依赖的舒张的影响。方法:以血管条等长张力法测定ｏｘ－ＬＤＬ、Ｌ－精氧酸(Ｌ－ａｒｇｉｎｉｎｅ,Ｌ－Ａｒｇ)等对兔动脉内皮依赖的舒张功能的影响。结果:较低浓度的ｏｘ－ＬＤＬ(５０μＧ·ｍｌ－１)明显抑制颈动脉经乙酰胆碱介导内皮依赖的舒张,而不抑制非内皮依赖的舒张。Ｌ－Ａｒｇ可部分逆转ｏｘ－ＬＤＬ密度脂蛋白引起的颈动脉内皮依赖的舒张功能损害。结论:ｏｘ－ＬＤＬ可抑制兔颈动脉内皮依赖的舒张而不影响基底动脉内皮依赖的舒张,补充Ｌ－Ａｒｇ可改善受损的内皮依赖的舒张功能。Aim: To compare effects of oxidized low-density lipoprotein (ox-LDL) on endothelium-dependent relaxation of intracranial and extracranial arteries in rabbits. Methods: Relaxation in precontracted vessels to acetylcholine and sodium nitroprusside were evaluated after exposure to LDL, ox-LDL or L-Arginine, et al by isometric tension methods. Results: After exposure to ox-LDL (50 μg·ml-1), relaxation to acctylclioline was impaired significantly in carotid but not in basilar artery. L-Arginine can partially normalize the impairment above. Relaxation to nitroprusside was not significantly impaired by ox-LDL in both arteries. Conclusion: ox-LDL impairs endothelium-dependent relaxation in the carotid but not in basilar artery. L-Arginine can improve the impaired endothelium-dependent relaxation.

关 键 词：氧化低密度脂蛋白 内皮依赖 舒张功能 颈动脉 基底动脉 兔 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]