红细胞免疫在冠心病发病机制中的作用  

Effect of red cell immune system in the pathogenesis of coronary atherosclerotic heart disease

作　　者：聂英坤[1] 朱秀英[1] 武小薇[1] 霍宏[1] 

机构地区：[1]哈尔滨医科大学附属第二医院老年病科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2001年第6期444-445,共2页Journal of Harbin Medical University

摘　　要：目的　探讨红细胞免疫功能在冠心病 (CAD)发病免疫机制中的作用。方法　对 32例CAD病人及 2 5例正常人 (NC)采用郭峰法检测了红细胞免疫功能。结果　①CAD患者红细胞C3b受体花环率显著低于NC组 (P <0 .0 1) ,且CAD各分型间均有显著差异 (P <0 .0 1) ;②CAD患者循环免疫复合物 (IC)受体花环率明显高于NC组 (P<0 .0 1) ,各分型间差异显著 (P <0 .0 1) ;③CAD患者红细胞促进因子 (RFER)显著低于NC组 (P <0 .0 1) ,各分型间差异显著 (P <0 .0 1) ;抑制因子 (RFIR)显著高于NC组 (P <0 .0 0 1) ,除不稳定心绞痛与稳定心绞痛间无差异 (P >0 .0 5 )外 ,其它各分型间均有差异 (P <0 .0 5 ) ;④CAD患者IC花环率、RFER及RFIR与红细胞C3b受体花环率之间具有明显的相关性。结论　红细胞免疫功能低下是冠心病的重要发病因素 ,对冠心病的分型。Objective To investigate the changes and effects of red cell immune system in the pathogenesis of coronary atherosclerotic heart disease (CAD).Methods The immune function of red cell was measured by Guo Feng's method in 32 patients with CAD and 25 subjects with normal controls(NC).Results ①The rate of red cell C3b receptor rosette was significantly lower than that of control group ( P <0.01),and there was significant difference between any two type of CAD ( P <0.01);② The rate of immune complex rosette was significantly higher than that of control group ( P <0.01),and there was significant difference between any two type of CAD ( P <0.01).③The activity of enhanced factor of red cell immune abherence (RCIA) in patients group was markedly lower than that of control group and there was marked difference between any two type of CAD ( P <0.001); The activity of inhabited factor of RCIA in patients group was markedly higher than that of control group ( P <0.001) and there was marked difference between any tow type of CAD ( P <0.01) besides there was not significant different between the stable angina pectoris (SAP) and the unstable angina pectoris(UAP) ( P >0.05);④The rate of red cell C3b receptor rosette was more negatively related to the rate of immune complex rosette and the activity of enhanced factor of RCIA respectively in patients with CAD, while highly positive correlation was present to the activity of inhabited factor of RCIA.Conclusion The decreasing function of reduced red cell immune system play an important role in leading to the pathogenesis of CAD. These changes may be helpful in indicating the severity of CAD and diagnosing the disease early and improving therapy in CAD patients.

关 键 词：红细胞 免疫系统 冠心病 C3B受体花环率 IC受体花环率 

分 类 号：R541.4[医药卫生—心血管疾病]