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作 者:王英杰[1] 董家鸿[1] 王宇明[1] 王曙光[1] 别平[1] 刘俊[1] 牛润章[1] 何念海[1] 刘国栋[1] 李嘉佳[1] 文红伟[1] 罗宾伟[1]
出 处:《中华肝脏病杂志》2001年第4期212-213,共2页Chinese Journal of Hepatology
基 金:全国优秀博士专项基金(199947);国家自然科学专项基金资助项目(30027001)
摘 要:目的观察并评价混合人工肝支持系统联合肝移植在救治重型病毒性肝炎(重型肝炎)中的作用与疗效。方法采用自行研制的体外混合人工肝支持系统对 8例中晚期重型肝炎患者进行人工肝过渡支持治疗, 3~ 14 d后行原位肝移植术。结果8例重型肝炎患者经混合人工肝支持,肝衰竭得到有效控制,均成功等到肝移植。肝移植后4例存活,存活率为50%,另4例因肺部感染、肝肾综合征等死亡。结论人工肝支持系统与肝移植联合可作为中晚期重型肝炎肝衰竭患者治疗的有效手段。Objective To observe and investigate the efficacy of the hybrid artificial liver support system plus liver transplantation in the treatments of patients with severe viral hepatitis. Methods Eight severe viral hepatitis patients with metaphase and advanced stage liver failure received the artificial liver support using a self-aommand extracorporeal hybrid artificial liver support system and orthotopic liver transplantation after the artificial support for 3-14days. Results The liver failure of the 8 patients was controlled by the hybrid artificial liver support effectively. All patients were successfully bridged to orthotopic liver transplantation. Four out of the eight patients survived after transplantation. Four patients died of pulmonary infection or hepatorenal syndrome. Conclusions Artificial liver support system conbined with liver transplantation can be regarded as an efficient measure for the treatment of metaphase and advanced stage patients of severe viral hepatitis.
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