HLA-DR4基因与类风湿关节炎的关联性研究  

Association of HLA-DR4 gene with rheumatoid arthritis

作　　者：张芳[1] 李兴福[2] 潘正论[2] 

机构地区：[1]徐州医学院第二附属医院风湿科,江苏徐州221006 [2]山东大学齐鲁医院风湿科,山东济南250012

出　　处：《徐州医学院学报》2001年第6期474-476,共3页Acta Academiae Medicinae Xuzhou

基　　金：山东省卫生厅科研基金资助课题 (9733)

摘　　要：目的　探讨人类白细胞抗原HLA -DR4基因与类风湿关节炎 (RA)的关联性。方法　采用特异性引物聚合酶链反应 (PCR -SSP)方法对山东地区汉族人群 132例类风湿关节炎患者及 130例正常健康者的HLA -DR4基因进行分析 ,并测定其基因频率。结果　HLA -DR4基因在 132例类风湿关节炎患者中的基因频率 (4 6 .2 % )显著高于其在 130例正常对照组中的基因频率 (19.2 % ,χ2 =2 1.6 2 4,P <0 .0 1)。结论　HLA -DR4基因与山东地区人群的类风湿关节炎易感性有关联。Objective To investigate the association of HLA-DR4 gene with rheumatoid arthritis (RA) in the population of Han nationality of Shandong province. Methods The method of PCR amplification with sequence-specific primers (PCR-SSP) was used to determine the HLA-DR4 genotype in 132 patients with RA and 130 healthy controls from the population of Han nationality in Shandong province. Results The frequency of HLA-DR4 gene was higher in RA patients (46.2%) than in normal subjects (19.2%). The difference was very significant (χ 2 =21.624,P<0.01). Conclusion The HLA-DR4 gene is associated with the susceptibility to RA in the population of Han nationality in Shandong province.

关 键 词：类风湿关节炎 人类白细胞抗原 聚合酶链反应-序列特异性引物 HLA-DR基因 

分 类 号：R593.22[医药卫生—内科学]