野黄芪甙元对实验性糖尿病大鼠肾脏的保护作用  

Renal Protective Effect of Erigeron Breviscapus in Diabetic rats

作　　者：吴文清[1] 李英[1] 赵金彩[1] 薛静[1] 李荣芬[1] 于洁[1] 王秀芬[1] 顾连方[1] 

机构地区：[1]河北医科大学第三医院肾内科,石家庄050051

出　　处：《中国中西医结合肾病杂志》2001年第8期444-446,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的 :观察野黄芪甙元对实验性糖尿病大鼠肾脏的保护作用。方法 :大鼠随机分为正常对照组、糖尿病组、野黄芪甙元治疗组。腹腔注射链脲佐菌素建立糖尿病动物模型 ,分别于 4、6周测定血糖、Scr、BUN、Ucr、尿蛋白、Ccr、肾重 /体重 ;肾小球平均面积 (MGPA)、平均体积 (MGV) ,对电镜片进行形态学观察。结果 :野黄芪甙元治疗后肾脏肥大指数、尿蛋白较糖尿病组明显减少 ,肾功能、体视学指标明显改善。结论 :中药野黄芪甙元可以改善糖尿病大鼠肾脏功能和结构的损伤 。Objective: To observe the renal protective effect of Erigeron brevis capus in diabetic rats.Methods: The rats were randomly divided by following groups:normal control rats,sreptoxotocin diabetic rats and diabetic rats treated with Erigeron breviscapus.The renal function?proteinuria and profile of kidney hy-pertrophy were observed after treatment,The renal tissue were observed by light microscopy and electron mi-croscopy.Results: Kidney hypertrophy index(P<0 05),urinary albumin excretion (P<0 05)in diabetic rats of Erigeron breviscapus ureated group were significantly lower than diabetic rats untreated rats,meanwhile,renal pathologic changes in diabetic rats of Erigeron breviscapus treated group were improved.Conclusion: Erigeron breviscapus has some renal protective effect on diabetic rats.

关 键 词：野黄芪甙元 糖尿病肾病 DN 实验药理学 

分 类 号：R285.5[医药卫生—中药学]