老年慢性肺心病脂质过氧化研究  

A study on lipide peroxide of aged chronic pulmonary heart disease.

作　　者：刘韵蝉[1] 梅元英[1] 唐筑灵 

机构地区：[1]贵阳医学院附属医院,550001 [2]贵州省老年医学研究所

出　　处：《中国民政医学杂志》2001年第4期211-212,共2页Medical Journal of Chinese Civil Administration

摘　　要：目的 :研究老年慢性肺心病患者脂质过氧化损伤与病情演变的关系及其衰老的影响。方法 :采用硫代巴比妥酸比色法测定血清过氧化脂质 (LPO) ,放射免疫法测定超氧化物歧化酶 (SOD)。结果 :三组病人上述指标差异有显著性 (P <0 0 1) ,肺心病急性发作期又高于肺心病缓解期 (P <0 0 5 ) ,结论 :老年肺心病患者存在脂质过氧化反应的增强 ,在肺心病病情变化的不同时期 ,氧自由基 (OFR)对肺组织的损伤与病情密切相关 。Objectives:To study damage,development and senile on lipide peroxide of aged chronic pulmonary heart disease.Methods:Measuring LPO by thiobarbituric acid colorimetric measure and measuring SOD by radio\|immunity measure.Results:LPO and SOD had significant difference among three groups of patients ( P< 0 01).LPO and SOD of pulmonary heart disease in acute stage were higher than that of remission stage( P< 0 05).Conclusion:Lipide peroxide reaction of aged pulmonary heart disease patients was serious and damage level of lung that was caused by OFR was correlated with stage of the illness.The old and feeble made the disease worese.

关 键 词：肺心病 氧自由基 过氧化脂质 超氧化物歧化酶 

分 类 号：R541.5[医药卫生—心血管疾病]