SD大鼠与Wistar大鼠心房特殊颗粒的比较研究  

Comparative Study of Atrial Specific Granules of SD Rats and Wistar Rats

作　　者：田宗文[1] 丁成萦[1] 王乔[1] 曾庆云[1] 戴冀斌[1] 周新华[1] 李萍 

机构地区：[1]武汉大学基础医学院人体解剖学教研室,武汉430071 [2]湖北省药检专科学校基础医学教研室,武汉430060

出　　处：《武汉大学学报（医学版）》2001年第2期104-106,共3页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金资助 (项目编号 97J0 74)

摘　　要：目的 :比较研究SD和Wistar两种不同种系大鼠心房特殊颗粒的超微结构和含量的变化。方法 :透射电镜观察和立体计量学分析。结果 :SD大鼠心房特殊颗粒 (ASG)可分为A、B两型 ,A型颗粒多见 ,含电子致密颗粒核心 ;B型少见 ,为一均匀浅淡的纤维状核心 ,且两型颗粒的界膜清晰可见。而Wistar大鼠ASG未见有B型颗泣 ,颗粒界膜不很明显。立体计量结果为SD大鼠ASG的颗粒平均直径 (D)明显大于Wistar大鼠 (P <0 .0 0 1) ;而SD大鼠体密度 (Vv)和数密度 (Nv)则明显小于Wistar大鼠 (P <0 .0 0 1)。结论 :证明两种不同种系大鼠ASG的超微结构和含量存在差别。Objective:To study comparatively the ultrastructure and content of atrial specific granules(ASG) in SD rats and Wistar rats.Methods:It was obserred and analysed by the transmission electron,image manipulation system.Results:ASG was classified as A,B types in SD rats,type A granules were in the majority and contained a more dense core;type B granules were in the minority and were characterized by a pale,fibrogranule core,the membrane of A,B type granules was clear, but not type B granules and membrane lysis of some granules in Wistar rats. The mean diameter of the granules in SD rats Stereological results was more than that in Wistar rats(P<0.001). The proportional volume and numerical density of the granules in SD rats were smaller than those in Wistar rats (P<0.001).Conclusion:The results of this study indicate there may be different in the ultrastructure and content of ASG between SD and Wistar rat.

关 键 词：心房特殊颗粒 超微结构 心钠素 大鼠 

分 类 号：R322.11[医药卫生—人体解剖和组织胚胎学]