板蓝根化学成分研究(Ⅰ)  

Studies on chemical constituents from root of Isatis indigotica Ⅰ

作　　者：刘云海[1] 秦国伟[2] 丁水平[1] 吴晓云[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院,湖北武汉430030 [2]中国科学院上海药物研究所,上海200031

出　　处：《中草药》2001年第12期1057-1060,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助课题 ( No39170 877);卫生部科学研究基金课题 ( No98-2 -110 )

摘　　要：目的　提取分离板蓝根化学成分。方法　板蓝根用 95 %乙醇渗漉 ,用不同极性溶剂分级萃取 ,再分别用硅胶和大孔树脂作柱层析分离 ,测定纯化合物的理化常数和波谱数据 ,鉴定化学结构。结果　从板蓝根中分得 2个化合物 ,分别命名为依靛蓝双酮 (isaindigotidione, ) ,(E) -二甲氧羟苄吲哚酮〔(E) - 3- (3′,5′- dimethoxy- 4′- hydroxy-benzylidene) - 2 - indolinone, 〕。结论　 和 为Object To extract and separate the chemical constituents from the root of Isatis indigotica Fort (Cruciferae) Methods The root of I. indigotica was percolated with 95% ethyl alcohol, partitioned in solvents of different polarities and finally isolated on silica gel and macroporous resin columns The purified compounds obtained were identified and structurally elucidated by their physicochemical properties and spectral analysis Results Two compounds were obtained and named as isaindigotidione (Ⅰ) and (E)-3-(3′, 5′-dimethoxy-4′-hydroxybenzylidene)-2-indolinone Conclusion The two compounds were new

关 键 词：板蓝根 依靛蓝双酮 (E)-二甲氧羟苄吲哚酮 中药 化学成分 

分 类 号：R284.1[医药卫生—中药学]