VP方案结合中药治疗成人慢性特发性血小板减少性紫癜临床研究  

Clinical Study on Treatment of Adult Chronic Idiopathic Thrombocytopenic Purpura by VP Regimen Combination Medical Herbs

作　　者：孙碧红[1] 唐志民[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《华夏医学》2001年第6期793-795,共3页Acta Medicinae Sinica

摘　　要：目的 :观察 VP方案结合中药治疗成人慢性特发性血小板减少性紫癜 (CITP)临床疗效 ,探讨可能的疗效机制。方法 :设立 VP方案结合中药治疗组 (简称治疗组 ) 39例和 VP方案对照组 (简称对照组 ) 4 0例 ,用现代药理学及免疫学对疗效机制进行探讨。结果 :治疗组显效率、良效率、总有效率分别为 2 5 .6 %、48.7%、89.7% ;对照组为 17.5 %、30 .0 %、75 .0 % ;两组间总有效率比较有显著性差异 (P<0 .0 1)。治疗组无论在血小板恢复、出血症状改善还是在起效时间上明显优于对照组 (P<0 .0 1)。部分免疫学检查显示 :治疗前 ,CITP患者体液免疫及血小板功能异常 ;治疗后 ,治疗组 CITP患者体液免疫及血小板功能恢复 (P<0 .0 1)。而激素及免疫抑制剂的副作用经中药拮抗 ,得到减轻或消失。结论 :VP方案结合中药治疗成人 CITP临床疗效可靠 。Objective: To observe the clinical effect of treatment of adult chronic idiopathic thrombocytopenic purpura (CITP) by VP Regimen Combination Medical Herbs, and study the possible mechanism. Methods: Effect of 39 patients of CITP in treatment group treated by VP Regimen Combination Medical Herbs and 40 patients in the control group treated by VP Regimen were observed and compared. Their modern pharmacology and immunology were determined for exploring the mechanism. Results: The markedly effective, improved and total effective rate of the treatment group were 25 6%, 48 7% and 89 7%; while those of the control group were 17 5%, 30 0% and 75 0% respectively, the difference between the two groups was significant ( P <0 01). The effect of the treatment group was better than the control group in platelet count restoring, hemorrhagic synptoms improving and effect initiating ( P <0 01). Partly immunologic test showed that the humoral immune function as well as platelet function were abnormal in CITP patients. These functions were improved after treatment, and the effectiveness of the treatment group was significantly superior to that of the control group. The ill effect of hormone and immnuno suppressive drugs to obtain relieving and disappearing to go through Medical Herbs resistancing. Conclusions: VP Regimen Combination Medical Herbs is reliable in treating adult CTTP clinically. Its mechanism might be due to its recovery of platelet count and function.

关 键 词：VP方案 成人 慢性特发性血小板减少性紫癜 血小板抗体 中西医结合疗法 免疫学检查 

分 类 号：R554.6[医药卫生—血液循环系统疾病] R558.2[医药卫生—内科学]