异常子宫出血与雌孕激素水平及其受体关系的研究  

Study on the relationship between abnormal endometrorrhagia and estrogen,progestogen level and its receptor.

作　　者：范利[1] 叶文珏[1] 方芳[1] 袁兰珍[1] 敖铮[1] 

机构地区：[1]北京铁路分局中心医院妇产科,100070

出　　处：《中国实用妇科与产科杂志》2002年第2期92-95,共4页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨异常子宫出血时雌、孕激素水平和子宫内膜组织中相应受体的量化关系。方法　使用宫腔镜技术对 13 0例异常子宫出血的子宫内膜定位取材 ,运用葡聚糖活性炭饱和分析法 (DCC法 )对雌激素受体(ER)与孕激素受体 (PR)定量检测。用放免法同步测定雌激素 (E2 )孕激素 (P)水平 ,结合病理检查结果进行分析 ,并与 3 0例月经正常、输卵管阻塞妇女对照。结果　①无排卵型功能血 :E2 水平及ER、PR含量与子宫内膜增生程度呈正相关。②黄体功能不全 :E2 水平和ER、PR含量均低于对照组 (B) (P <0 0 5 )。③黄体功能萎缩不全 :P水平明显低于对照组 (B) (P <0 0 5 )。ER、PR含量均高于对照组 (B) (P <0 0 5 )。④子宫内膜息肉 :E2 水平和ER、PR含量均高于对照组 (A) (P <0 0 1,P <0 0 5 )。⑤子宫肌瘤引起的异常子宫出血 :E2 和P水平和ER、PR含量均高于对照组 (A) ( P <0 0 1,P <0 0 5 )。⑥药流术后出血 (除外妊娠物残留 ) :E2 水平和ER含量均高于对照组 (A) (P <0 0 1)。P水平和PR含量低于对照组 (A) (P <0 0 5 )。结论　从激素受体角度探讨激素水平与异常子宫出血的关系 。Objective To evaluate the quantitative relationship between the estrogen,progestogen level and the related receptors of endometrium under the condition of abnormal endometrorrhagia.Methods We locatively obtain the endometrium of 130 cases' abnormal endometrorrhagia by hysteroscope technique.Estrogen receptor(ER)and progestogen receptor(PR) were quantitatively measured by DCC(dextran activated carbon saturation analysis assay),while the estrogen(E 2)and progestogen(P)level in phase via radio immunity were assayed.Combined with pathologic test,we analyzed the results and compared them with those in 30 cases' regular menses,fallopian tube barrage.Results ①No ovulation functional hemorrhage:E 2 level,ER and PR contents were positively related with the hyperplasia degree of endometrium.②Corpus luteum function incompetence:E 2 level,ER and PR contents were all below those of control(B)(P<0\^05).③Atrophy incompetence of corpus luteum function:P level was obviously lower than that of control group(B)(P<0\^05),while ER and PR contents were all higher significantly(P<0\^05).④Polypi of endometrium:E 2 and P level,ER and PR content were all higher than those in control group(A)(P<0\^01,P<0\^05).⑤Abnormal endometrorrhagia caused by hysteromyoma:E 2,P,ER and PR content were all above the level in control group(A)(P<0\^01,P<0\^05).⑥Hemorrhage after drug abortion(except residual):E 2 level and ER content were all above those in control group(A)(P<0\^05).P level and PR content were all below those in control group(A)(P<0\^05).Conclusion To evaluate the relationship between hormone level and abnormal endometrorrhagia from the view of hormone receptors,so as to make a new path for the abnormal endometrorrhagia diagnosis and treatment.

关 键 词：异常子宫出血 雌激素 孕激素 雌激素受体 孕激素受体 

分 类 号：R711.74[医药卫生—妇产科学]