补骨脂素和异补骨脂素体外透皮特性研究  

Study on Transdermal Permeability of Psoralen and Isopsoralen

作　　者：张宁[1] 徐莲英[1] 

机构地区：[1]上海中医药大学,上海200032

出　　处：《中成药》2002年第1期7-9,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨补骨脂素和异补骨脂素透皮特性。方法 :采用V C水平扩散池 ,和常用促透剂乙醇、氮酮、甘油研究补骨脂素和异补骨脂素在裸鼠皮肤中的透过性。结果 :补骨脂素和异补骨脂素能够透过裸鼠皮肤 ,异补骨脂素渗透系数较补骨脂素大 ;所选用的促渗剂中以 10 %乙醇 - 1%氮酮的复合促渗剂为好。结论 :本研究为补骨脂透皮制剂研究提供了依据。Objective:To study the transdermal permeability of Psoralen (Pro) and Isopsoralen (Isopro). Methods:V C two compartment was adopted to research the permeability deferences between Pso and Isopso in nude mouse skin in vitro, and investigated the effect of penetration enhancers, such as EtOH, azone and glycerol on the permeability of them. Results: Pso and Isopso are suitable compounds for transdermal delivery system and the permeability coeffient of Isopso is larger than that of Pso. 10% EtOH-1% Azone greatly increased the permeability coefficient. Conclusion: The results can offer reference for Psoralea corylifolia TDS.

关 键 词：补骨脂素 异补骨脂素 体外透皮特性 经皮给药制剂 

分 类 号：R285.1[医药卫生—中药学]