云芝糖肽的镇痛作用及其机理的初步分析  

Analgesic Effect of Yunzhi Polysaccharopeptide and Preliminary Analysis of Its Mechanism

作　　者：殷伟平[1] 龚珊[1] 蒋星红[1] 顾振纶[2] 

机构地区：[1]苏州大学医学院神经生物学研究室,江苏苏州215007 [2]苏州大学医学院药理学教研室,苏州中药研究所江苏苏州215007

出　　处：《中成药》2002年第1期41-43,共3页Chinese Traditional Patent Medicine

基　　金：香港保健协会资助项目

摘　　要：目的 :了解云芝糖肽的镇痛作用和初步机理。方法 :用热板法和电刺激 嘶叫法分别测定小鼠和大鼠的痛阈。结果 :云芝糖肽 (PSP)以 1.0 g/kg的剂量灌胃 ,每日 1次 ,连续 7日 ,可以出现非常明显的镇痛作用。这种镇痛可以持续 2h多。损毁下丘脑内侧基底部后 ,PSP的镇痛作用消失。结论Objective:To observe the analgesic effect of Yunzhi polysaccharopeptide (PSP) and analyze its mechanism. Methods: The hot plate test in mice and the tail stimulation vocalization test in rats were used.Results: PSP administered po at a dose of 1.0 g/kg for 7 days could produce a significant analgesic effect, which could last for more than two hours. The analgesic effect of PSP disappeared after lesion of mediobasal hypothalamus. Conclusions: PSP could elicit a central analgesic effect.

关 键 词：云芝糖肽 镇痛 热板法 电刺激-嘶叫法 下丘脑内侧基底部 作用机理 动物实验 

分 类 号：R286.11[医药卫生—中药学] R285.1[医药卫生—中医学]