RP-HPLC分离制备银杏酚酸类单体成分  

Separation and Preparation of Ginkgolic Acid α_1 by RP-HPLC

作　　者：倪澜荪 林雁飞 张鉴[2] 

机构地区：[1]湖北出入境检验检疫局武汉,430022 [2]中国科学院等离子体研究所生物工程中心,合肥230031

出　　处：《中成药》2002年第1期54-56,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :研究银杏酸α1单体的制备技术。方法 :以乙醇为提取溶剂 ,获得的乙醇浸膏经硅胶吸附能除去大部分极性较大的杂质 ,RP HPLC分离制备银杏酸α1单体。结果 :银杏酸α1的提取率达 84%以上 ,纯度可达 98%。结论 :该方法简便易行 ,大大降低了工作量。Objective:To develope a method for the separation and preparation ginkgolic acid α 1. Methods: Ginkgolic acids were extracted by alcohol, and adsorbed by silica gel to remove most of the polar impurities. It was preparated with RP HPLC. Results: The extraction ratio of ginkgolic acid α 1 by this extraction process was above 84%, and the purity of ginkgolic acid α 1 reached 98%. Conclusion: This procedure is simple and relatively effective.

关 键 词：银杏酸 制备工艺 反相高效液相色谱法 心脑血管药物 

分 类 号：R284.2[医药卫生—中药学]