病毒性肝炎患者I型前胶原羧基端肽及表皮生长因子评价  

Carboxy Terminal Peptide of Type I Procollagen and Epidermal Growth Factor in Patients with Different Viral Hepatitis

作　　者：韩丽红[1] 龚守军[1] 李光明[1] 李也冰 徐斌[1] 

机构地区：[1]武警上海总队医院,上海201103

出　　处：《标记免疫分析与临床》2001年第4期193-194,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：通过观察各型病毒性肝炎及肝硬化患者血清Ⅰ型前胶原羧基端肽 (PICP)及表皮生长因子 (EGF)水平 ,以评价其在肝纤维化中的临床意义。本文采用放射免疫分析方法测定了 134例病毒性肝炎患者和 30名正常人(对照组 )的血清PICP及ECF水平。结果表明急性肝炎组两指标与对照组相比无显著差异 (P >0 .0 5 ) ,而慢性肝炎轻中型组、慢性肝炎重型组及肝硬化组两指标与对照组相比 ,均有显著性差异 (P <0 .0 5 - 0 .0 1) ,其中慢性肝炎重型组两指标水平最高。以上结果说明 ,测定血清PICP及EGF水平可以反映肝纤维化程度及慢性肝病的活动度 。The article is to observe the serum levels of carboxy terminal peptide of type I procollagen(PICP)and epidermal growth factor(EGF)in the patients with viral hepatitis and cirrhosis. The serum PICP and EGF were detected in 164 cases by RIA. The results indicated that two indexes increased significantly in patients with severe chronic hepatitis,chronic persistent hepatitis and post hepatitis cirrhosis compared with normal control( P <0.05, P <0.01). But there weren't different between acute hepatitis and control( P >0.05).The results showed that detection of serum PICP and EGF may be valuable diagnostic markers to assess the degree of liver inflammation and fibrosis in viral liver diseases.

关 键 词：病毒性肝炎 Ⅰ型前胶原羧基端肽 表皮生长因子 肝纤维化 检测 

分 类 号：R512.6[医药卫生—内科学]