二种细胞因子在心脑血管疾病中的临床应用  

The Clinical Significance of Changes in the TNF and IL-1β in Cardiovascular and Cerebrovascular Disease

作　　者：赵豫琴[1] 保勇[1] 余坷[1] 陈玉清[1] 涂勇[1] 曾英[1] 刘德英[1] 

机构地区：[1]成都市第二人民医院放免中心,四川成都610017

出　　处：《标记免疫分析与临床》2001年第4期197-199,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨肿瘤坏死因子 (tumornecrosisfactor,TNF)和白细胞介素 1β(interleukin - 1β ,IL - 1β)二种细胞因子在心脑血管疾病中的水平变化及临床应用 ,本文用RIA分别对 5 1名正常人和 46例冠心病、48例高血压和 34例脑梗死患者进行检测。结果表明 :冠心病、高血压和脑梗死患者血清中这二种细胞因子含量 ,均高于对照组(P <0 .0 1)。本文提示 :TNF和IL - 1β二种细胞因子均参与了冠心病、高血压和脑梗死疾病的病理生理过程 ,是冠心病。To study the changes in tumor necrosis factor(TNF)and interleukin-1β (IL-1β) level in cardiovascuar and cerebralvascular diseases, the concentration of the two CK factors was testde by RIA in 51 control, 46 cases of coronary artery disease(CAP), 48 cases of hypertension patients (HP) and 34 cases of cerebral infarction(CI). The results showed that the concentrations of TNF and IL-1β in the serum of the cases of hypertension and cerebral infarction were much higher than that of the control group ( P <0.01). It indicated that the two cell factors (TNF and IL-1β) may play a certain role in the pathophysiological processes of the CAP? HP and CI. The two factors may be an important indicator of the three disease.

关 键 词：TNF IL-1Β RIA 冠心病 高血压 脑梗死 细胞因子 脑血管疾病 

分 类 号：R817.1[医药卫生—影像医学与核医学]