支气管哮喘患者外周血白细胞CD18和血清sICAM-1变化及意义  

The Change and Significance of β2-integrin and Soluble Intercellular Adhesion Molecule-1 in Periheral Blood with Bronchial Asthmatics

作　　者：甘华山[1] 潘晓娟[2] 陈友琴[3] 朱家媛[4] 

机构地区：[1]四川省交通厅公路局医院,四川成都610041 [2]四川省成都市第九人民医院,四川成都610041 [3]华西医科大学生物医学工程研究室,四川成都610041 [4]华西医科大学组织胚胎学教学研究室,四川成都610041

出　　处：《华西医学》2001年第4期416-417,共2页West China Medical Journal

摘　　要：目的 :探讨支气管哮喘患者外周血白细胞粘附分子β2 整合素 (β2 -integrin ,CD18)和血清可溶性细胞间粘附分子 - 1(sICAM - 1,CD5 4)变化及其意义。方法 :采用流式细胞仪检测支气管哮喘患者外周血白细胞CD18和血清sICAM - 1的表达。结果 :(1)支气管哮喘患者外周血白细胞CD18和血清sICAM - 1表达呈显著正相关 (γ =0 934 ,P <0 0 5 )。结论 :支气管哮喘患者外周血白细胞CD18和血清sICAM - 1表达增加 ,可能是支气管哮喘重要的发病机制之一。Objective:To investigate the change and significance of CD18 and soluble intercellular adhesion molecule-1 in periheral blood with bronchial asthmatics.Method:The expression of CD18 and sICAM-1 were determined by flow cytometry.Result:①The expression of CD18 and sICAM-1 were significant increased compare with control( P <0 05) ②The positive correlation was found between CD18 and sICAM-1 in bronchial asthma patients (γ=0.934, P <0.05).Conclusion:The increase of expression CD18 and sICAM-1 may play an important role in the pathogenesis of bronchial asthma.

关 键 词：支气管哮喘 Β2整合素 可溶性细胞间粘附分子-1 白细胞CD18 

分 类 号：R562.25[医药卫生—呼吸系统]