复方替硝唑凝胶剂的制备与质量控制  

Study on the Preparation of Tinidazole Compound Gel and its Quality Controlled

作　　者：杨利平[1] 石林[1] 彭静[2] 李里[1] 

机构地区：[1]华西医科大学附属第一医院药剂科,四川成都610041 [2]成都军区总医院,四川成都610083

出　　处：《华西医学》2001年第4期452-453,共2页West China Medical Journal

摘　　要：目的 :研制复方替硝唑凝胶剂并制定质量控制标准。方法 :以替硝唑和氯霉素为主药制成凝胶剂 ,并用双波长法于 2 72 5nm、 34 3 5nm处测定氯霉素的平均回收率分别为 10 2 17% (RSD 1 44 % ) ;98 40 % (RSD1 47% )。结论 :该制剂制备工艺简便 ,质量控制可行。Objective:To investigate the preparation of Tinidazole Compound Gel and set up its quality controlled.Methods:The preparation of Tinidazole Compound Gel containing Tinidazole and Chloromycin.The concentration of Chloromycin was determined by use of Double-Wavelength UV method and the concentration of Tinidazole was also determined by UV at 365nm,which 0 1M NaOH as a solution.Results:The average recoveries of Tinidazole and Chloromycin were 102 17%(RSD 1 44%);98 40%(RSD 1 47%)respectively.Conclusions:The method was simple and reliable.

关 键 词：替硝唑 氯霉素 复方替硝唑凝胶剂 制备 质量控制 

分 类 号：R943[医药卫生—药剂学]