人锰超氧化物歧化酶(hMn-SOD)的研究进展  

Progress in the Studies of Human Manganese Superoxide Dismutase

作　　者：张艳红[1] 廖晓全[1] 袁勤生[1] 

机构地区：[1]华东理工大学生物工程学院生物反应器国家重点实验室,上海200237

出　　处：《药物生物技术》2001年第6期352-356,共5页Pharmaceutical Biotechnology

摘　　要：人锰超氧化物歧化酶（ｈＭｎ－ＳＯＤ）是线粒体基质酶，其基因是诱导表达的。作为细胞内氧自由基的清除剂，具有抗衰老、提高细胞对氧应激反应的耐受性及抑制肿瘤发生等方面的作用。文章从ｈＭｎ－ＳＯＤ的结构、理化性质、分子生物学研究、与衰老、肿瘤的相关性及其临床应用等方面对其进行近期研究成果和未来发展趋势进行了综述。Human Manganese superoxide dismutase is a matrix enzyme in mitochondrion. It's gene is ex- pressed by indution. As a scavenger of oxygen free radical it has the function of antiaging, enhance the cell tolerance to oxygen stress and surpress tumor and so on. This paper reviewed current researching status and future developing trend on the aspects including physical and chemical character, molecular biology studies, the relativity to aging and tumor, clinical practice and so on.

关 键 词：人锰超氧化物歧化酶 衰老 氧应激反应 肿瘤 hMn-SOD 

分 类 号：Q55[生物学—生物化学]