蛇床子水提取液对小鼠S_(180)肉瘤的抑制作用  

INHIBITION OF THE WATER EXTRACTS OF CNIDIUM MONNIERI L. CUSS ON S\-\{180\} TUMOUR IN VIVO

作　　者：周俊[1] 殷学军[1] 王瑞[1] 仇东辉[1] 黄国香[1] 刘德祥[1] 胡边[1] 

机构地区：[1]兰州军区乌鲁木齐总医院,新疆乌鲁木齐830000

出　　处：《癌变．畸变．突变》2001年第3期160-163,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :研究蛇床子水提取液的体内抗肿瘤作用。方法 :通过S180 肉瘤移植建立荷瘤小鼠模型 ,然后对S180 荷瘤小鼠给予 4种剂量蛇床子水提取液后观察瘤重、小鼠生存天数及血清涎酸 (SA)等指标。结果 :剂量组 0 0 4mg/(g·bw·d)、0 2 1mg/(g·bw·d)、0 42mg/(g·bw·d)平均瘤重低于肿瘤对照组 (P <0 0 5 ) ,且能延长小鼠生存天数 (P <0 0 1)。抑瘤率依次为 34.2 %、6 3 6 %和 33 2 % ,动物生命延长率依次为 5 3 0 %、5 8 3 %和 47 0 %。结论 :蛇床子水提取液具有较强的抗肿瘤作用 ,有很好的利用前景 。Purpose: To study the antitumour effects of the water extracts of Cnidium monnieri L. cuss in vivo. Methods: Mice carrying S\-\{180\} tumor were given different doses of the water extracts, then the tumor weight, the survival days of the animals and the SA in serum were observed. Results: The tumor weight were lower than control group when the doses of water extracts were 0.04 mg/(g·bw·d), 0.21 mg/(g·bw·d) and 0.42 mg/(g·bw·d), The inhibitory rates were 34.2%, 63.6% and 33.2%, respectively. The water extracts also could extend the survival days of mice carrying S\-\{180\} tumor(P<0.01) and the extending rates were 53.0%, 58.3% and 47.0% in turn. Conclusion: The water extracts of cnidium monnieri L.Cuss had a good effect of antitumor. It is worth studying on it deeply.

关 键 词：蛇床子 S180肉瘤 实验药理学 

分 类 号：R286.913[医药卫生—中药学] R285.5[医药卫生—中医学]