HLA-DQA1、-DRB1等位基因与子宫内膜异位症和子宫腺肌病的比较性研究  

Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis

作　　者：宗利丽[1] 潘德京[2] 陈为明 何援利[1] 刘泽寰[2] 林江海[2] 徐安龙[2] 

机构地区：[1]第一军医大学珠江医院妇产科,广州510282 [2]中山大学生命科学院生物化学研究室

出　　处：《中华医学遗传学杂志》2002年第1期49-51,共3页Chinese Journal of Medical Genetics

基　　金：国家杰出青年基金 (3972 50 0 7)~~

摘　　要：目的　从免疫遗传学角度比较子宫内膜异位症和子宫腺肌病的异同。方法　采用顺序特异引物聚合酶链反应技术检测 5 1例子宫内膜异位症和 45例子宫腺肌病患者的 HL A- DQA1和 HL A- DRB1等位基因频率 ,并与 44名正常人比较。结果　两患者组 HL A- DQA1* 0 30 1等位基因频率 (8.8% ,5 .6 % )均明显低于正常对照组 ,差异有显著性 (Pc=0 .0 0 ,Pc=0 .0 0 ) ,而两患者组的 HL A- DQA1* 0 40 1等位基因频率 (7.8% ,10 .0 % )均明显高于对照组 ,差异有显著性 (Pc=0 .0 3,Pc=0 .0 1) ;两患者组之间 HL A-DQA1、- DRB1各等位基因频率比较 ,差异无显著性。结论　子宫内膜异位症及子宫腺肌病均与 HL A-DQA1* 0 30 1、* 0 40 1相关联 ,从 HL A- DQA1、- DRB1角度分析 ,子宫内膜异位症与子宫腺肌病的发病机理可能有共同之处。Objective To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis. Methods The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control. Results The frequencies of HLA-DQA1*0401(7.8%,10.0%) were significantly increased in the endometriosis group and the adenomyosis group ( Pc=0.03, Pc =0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups ( Pc=0.00,Pc =0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis. Conclusion The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.

关 键 词：子宫内膜异位症 子宫腺肌症 遗传易感性 人类白细胞抗原-DQA1基因分型 人类白细胞抗原-DRB1基因分型 顺序特异引物聚合酶链反应 

分 类 号：R711.71[医药卫生—妇产科学]