盐酸艾司洛尔对气管内插管应激反应的影响与给药时间的关系  

EFFECT OF ESMOLOL ON CIRCULATORY STRESS REACTION DURING TRACHEAL INTUBATION WITH THE TIME OF INTRAVENOUS ADMINISTRATION

作　　者：张海山[1] 高秀琴[1] 

机构地区：[1]胜利石油管理局中心医院,东营市257034

出　　处：《滨州医学院学报》2002年第1期35-37,共3页Journal of Binzhou Medical University

摘　　要：目的 :探讨盐酸艾司洛尔 ( ESM)用于预防气管内插管应激反应的临床效应。方法 :选择胸、腹及下肢择期全麻手术者 6 0例 ,按先后顺序随机将病例分成 A、B、C三组 ,每组 2 0例。 A组诱导前静注 ESM 1 .5mg/kg,1 min注完 ;B组 ESM改诱导后静注 ,注完后立即行气管内插管 ;C组用同容量生理盐水代替 ESM,三组诱导用药相同。结果 :A、B组收缩压 ( SDP)、舒张压 ( DBP)、平均动脉压 ( MAP)及心率 ( HR)除插管后即刻高于 ( P<0 .0 5 )术前基础值外 ,插管后 1、5、1 0 min以上各参数与基础值基本接近 ,而 C组 SDP、DBP、MAP及 HR插管后即刻明显高于 ( P<0 .0 1 )术前基础值 ,插管后 5 min以上各参数仍高于术前基础值 ( P<0 .0 5 ) ,且插管反应较 A、B两组剧烈。A组窦缓发生率明显高于 B组 ( P<0 .0 5 )。结论 :ESM对预防气管内插管的应激反应有一定的预防作用 ,但不足以完全抑制气管内插管的应激反应。将 ESM诱导后用药能有效地减少窦缓的发生。Objective:To investigate the effect of esmolol on circulatory response during tracheal intubation.Methods:Sixty adult patients scheduled for selective surgery in general anesthesia were randomly divided into three groups,A,B,and C(n=20).Group A,esmolol(ESM)1 5 mg/kg iv before induction;Group B,ESM 1 5 mg/kg iv after induction;Group C,0 9%NS iv before induction.Results:SBP,DBP,MAP,and HR remained unchangcd 1,5,10 min after endotracheal intubation in groups A and B,and increased immediately after intubation in group C( P <0 01).HR in group A decreased significantly ( P <0 05) as compared with that in group B.Conclusion:Intravenous administration of esmolol before endotracheal intubation could attenuate cardiovascular response,but could not depress the stress reaction completely.Intravenons administration of esmolol after induction could attenuate bradycardia.

关 键 词：全麻 盐酸艾司洛尔 气管内插管 血流动力学 预防 

分 类 号：R971.2[医药卫生—药品]