氟喹诺酮类药物对金黄色葡萄球菌的抗菌活性及利血平对其抗菌活性的影响  

Study on the Activities of Fluoroquinolones against Staphylococcus aureus and the Effect of Reserpine on These Activities

作　　者：钟利[1] 冯萍[1] 范昕建[1] 吕晓菊[1] 俞汝佳[1] 廖昉[1] 雷秉钧[1] 

机构地区：[1]四川大学华西医院传染科

出　　处：《华西医科大学学报》2002年第1期91-93,共3页Journal of West China University of Medical Sciences

基　　金：国家自然科学基金资助 (批准号 395 0 0 12 8

摘　　要：目的　了解氟喹诺酮类药物 (FQNS)对金黄色葡萄球菌 (金葡菌 )的抗菌活性及利血平对其抗菌活性的影响。方法　采用对倍稀释浓度琼脂平板法测定抗菌药物的最低抑菌浓度 (MIC)值 ,同法测定利血平对FQNS对金葡菌 MIC值的影响。结果　临床分离的耐药金葡菌及诱导耐药金葡菌对 FQNS存在明显的交叉耐药 ,但无明显的多重耐药 ;利血平能降低 FQNS对大多数金葡菌实验菌株的 MIC值 ,但 FQNS对敏感菌和耐药菌 MIC值降低的百分比无显著性差异 ;亲水性 FQNS对金葡菌实验菌株 MIC值的降低百分比明显高于疏水性 FQNS;FQNS对诱导耐药金葡菌 MIC值的降低尤为明显。结论　金葡菌对 FQNS存在明显的交叉耐药 ,而无明显的多重耐药 ;FQNS的主动外排泵是金葡菌所固有的 。Objective To investigate the activities of fluoroquinolones and the effects of reserpine on the activities of fluoroquinolones against S. aureus .Methods The minimal inhibitory concentration (MICs) and the effects of reserpine on MICs of fluoroquinolones against S. Aureus were determined using standard agar dilution method. Results Cross resistance to fluoroquinolones was found existing in S. aureus, but there was no remarkable multidrug resistance. The MICs of fluoroquinolones against many of S. aureus could be decreased by reserpine;Obvious decrease in MICs of fluoroquinolones against SA2 16 was observed;The decreasing percentage of MICs of fluoroquinolones against resistant strains was shown not significantly higher than that of sensitive strains. The decreasing percentage of MICs of hydrophilic fluoroquinolones against the strains studied was significantly higher than that of hydrophobic fluoroquinolones. Conclusions Cross resistance to fluoroquinolones has been found existing in S. aureus, whereas multidrug resistance is not seen in existence. The efflux of fluoroquinolones is normal in S. aureus; the amount of fluoroquinolones effluxed is related with the resistance of fluoroquinolones in S. aureus.

关 键 词：氟喹诺酮类药物 金黄色葡萄球菌 利血平 抗菌活性 

分 类 号：R969[医药卫生—药理学]