FHIT基因研究进展  

Advances of FHIT gene

作　　者：林亚华[1] 叶巧滔[2] 

机构地区：[1]第二军医大学海医系放射医学教研室,上海200433 [2]中国人民解放军第442医院外科,福建宁德352102

出　　处：《国外医学（放射医学核医学分册）》2001年第6期275-279,共5页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：FHIT基因是定位于染色体 3p14.2区域的候选肿瘤抑制基因 ,在许多肿瘤 ,特别是环境致癌物引起的上皮肿瘤中经常发生改变 ,在辐射引起的癌症中也有改变 ,参与细胞周期和细胞凋亡的调控 ,但其作用的机理尚未完全阐明。The FHIT gene located at chromosome 3p14.2 is a putative tumor suppressor gene. It is frequently altered in many tumors, particularly in tumors resulting from exposing to environmental carcinogens.In tumor that is caused by radiation, the FHIT gene is also altered. It is involved in the regulation of apoptosis and in cell cycle control. However, its mechanism is not completely clarified.

关 键 词：FHIT基因 肿瘤抑制基因 细胞凋亡 恶性肿瘤 辐射 

分 类 号：Q334.13[生物学—遗传学]