长期低剂量免疫抑制对肾移植受者淋巴细胞表型的影响  

Direction of lymphocyte phenotype in long term renal transplant recipients under low dosage of immunosuppressant and its clinical significance

作　　者：肖家全[1] 唐孝达[2] 王祥慧[2] 徐达[2] 周佩军[2] 凡杰[2] 温文倩[2] 

机构地区：[1]东南大学附属中大医院泌尿外科,南京210009 [2]上海市第一人民医院泌尿外科,肾移植中心

出　　处：《临床泌尿外科杂志》2002年第1期26-28,共3页Journal of Clinical Urology

基　　金：国家自然科学基金资助项目(No.39870706)

摘　　要：目的：探讨肾移植受者长期低剂量免疫抑制维持用药的免疫学基础。方法：采用多种单克隆抗体,以流式细胞仪为工具，对28例长期低剂量免疫抑制维持用药的肾移植受者外周血淋巴细胞表型进行检测，分析细胞表型与临床用药和移植效果的关系，并与常规剂量用药组和慢性移植肾失功能组比较。结果：低剂量组CD 95、NK及HLA-DR阳性细胞数目与正常人接近，而在常规剂量组和移植肾失功能组中，CD 95明显升高，NK细胞明显减少。结论：CD 95、NK及HLA-DR水平可用于评价长期肾移植受者的免疫状态，并有可能作为调整免疫抑制剂用量的参考指标。Purpose: To investigate the immunological characteristics in recipients under low dosage of immunosuppressant.Method: The lymphocyte phenotypes in 28 patients under low dosage of immunosupprssant were detected by flow cytometry, and the relationships between phenotypes and dosage of immunosuppressant and allograft function were analized.Result: The numbers of CD95、NK and HLA－DR positive cells in recipients under low dosage of immunosuppressant were similar to normal, while the number of CD95 was higher and NK was lower than those under conventional dosage of immunosuppressant or with chronic allograft dysfunction.Conclusion: The numbers of CD95、NK and HLA-DR positive cells can be used as parameters to evaluate the immune state in long term renal transplant survivals and to direct the usage of immunosuppressant.

关 键 词：肾移植 免疫抑制剂 淋巴细胞免疫表型 

分 类 号：R699.2[医药卫生—泌尿科学] R392.1[医药卫生—外科学]