tadenan对实验兔膀胱出口部分梗阻所致膀胱功能障碍的治疗作用  

Effects of tadenanR treatment on urinary bladder outlet dysfunction in rabbits

作　　者：王国民[1] 王杭[1] 张永康[1] 

机构地区：[1]复旦大学附属中山医院泌尿外科,上海200032

出　　处：《中华泌尿外科杂志》2001年第9期517-519,共3页Chinese Journal of Urology

摘　　要：目的　观察tadenan (太得恩 ,原名通尿灵 )对膀胱出口部分梗阻所致膀胱功能障碍的治疗作用。　方法　 2 0只新西兰雄性白兔分 4组每组 5只。A组为正常对照组 ,B、C、D组为实验组 ,A组行手术但不造成梗阻 ,B、C、D组手术造成膀胱出口部分梗阻。术后两周 ,B组予太得恩 10 0mg·kg-1·d-1口服 ,C组予花生油 (太得恩赋形剂 ) ,A、D组不给任何药物。饲养后解剖膀胱 ,取逼尿肌束标本于不同溶液中行电生理刺激观察其收缩功能 ,并以电子显微镜观察逼尿肌细胞超微结构。　结果　太得恩对膀胱出口部分梗阻所致的膀胱容量缩小有明显的保护作用 ;A组膀胱逼尿肌的收缩性明显优于D组及C组 ;D组和C组膀胱逼尿肌细胞中内质网明显扩张 ,线粒体水肿明显 ;而太得恩对逼尿肌细胞超微结构的病理改变具有保护作用。　结论　太得恩可保护膀胱逼尿肌收缩功能 ,对BPH有良好疗效。Objective To study the protective effect of tadenanR on the bladder contractile function following partial outlet obstruction. Methods 20 New Zealand white male rabbits were divided into 4 groups of 5 rabbits each. Control group received operation but not forming obstruction model where as other groups received operation forming obstruction model.Two weeks after operation, tadenanR group received tadenanR orally at 100 mg·kg -1 ·d -1 for three weeks; Peanut oil group received vehicle only (peanut oil) and the obstruction group did not receive any drugs for three weeks. Five weeks after operation, the weight and volume of each bladder was assessed, and 3 longitudinal strips(1.0 cm×0.5 cm) of each bladder musculature were mounted in individual baths including Thyrode's buffer?atropine?ATP?Ca 2+ -free and high K+ solusions for contractile study. The ultrastructure of detrusor cells was observed with electron-microscope. Results tadenanR did not reduce the bladder weight after partial outlet obstruction but had protective effect on the capacity of bladder.tadenan*R treatment resulted in a protective effect on the contractile response to field stimulation in all kinds of solutions when contrasted with obstruction group and peanut oil group. It also reduced the enlargement of endoplactmic reticulum and mitochondrion as compared with obstruction group and peanut oil group. Conclusions tadenanR has direct effect on prostate through the inhibition of β-FGF and it also has a protective effect on bladder function.So it is preferable in the treatment of BPH.

关 键 词：太得恩 膀胱出口梗阻 逼尿肌 膀胱功能障碍 动物实验 治疗 通尿灵 

分 类 号：R965[医药卫生—药理学]