老年人糖耐量低减的冠心病与β细胞功能及脂代谢的关系  

Association between the aged impaired glucose tolerance united coronary heart disease,and β cell function and lipometabolism

作　　者：季洪赞[1] 龚维忠[2] 杨继红[1] 李琳[1] 胡兰萍[3] 胡拥军[1] 商玮[1] 

机构地区：[1]南京军区南京总医院老年二科,江苏南京210002 [2]解放军政治学院门诊部 [3]南京军区南京总医院内科实验室,江苏南京210002

出　　处：《心脏杂志》2001年第6期448-449,452,共3页Chinese Heart Journal

摘　　要：目的 :探讨老年人糖耐量低减 ( IGT)的冠心病 ( CHD)与β细胞功能及脂代谢的关系。方法 :将 79例糖耐量低减老年人分为冠心病组 ( n=3 1)和非冠心病组 ( n=4 8) ;糖耐量正常 ( NGT)老年人 4 9例作为对照组。测定空腹胰岛素 /空腹血糖 ( FINS/ FBG)、胰岛素敏感指标 ( ISI)及血脂 ( TC,TG,HDL - C,TC/ HDL - C)并对结果进行分析比较。结果 :IGT冠心病组较之 IGT非冠心病组和 NGT组 ,在 FINS/ FBG,ISI差异有显著性 ( P<0 .0 5 ;P<0 .0 1) ,TC,TG,TC/ HDL - C的差异亦有显著性 ( P<0 .0 5 ,P<0 .0 5 ,P<0 .0 1) ,老年人 IGT组 ( n=79) FINS/ FBG,ISI较之老年人 NGT组显著减低 ( P<0 .0 1) ,脂代谢紊乱表现为高 TC/ HDL - C( P<0 .0 1)比值。结论 :老年人 IGT应尽早实施保护β细胞功能。AIM:To study the association between the aged impaired glucose tolerance united coronary heart disease and β cell function,lipometabolism. METHODS:79 case coronary heart disease of the senile IGT patients and 49 NGT of the senile were examined for β cell function and lipometabolism. The subjects were divided into three groups:CHD groups( n =31),not CHD groups( n =48) and NGT group ( n =49) .RESULTS:The β cell function (FINS/FBG,ISI) and lipometabolism (TC/HDL C) in the IGT group ( n =79) were marked different from those in the controls(NGT)( P <0.05, P <0.01). The β cell function and lipometabolism of the senile IGT patients( n =79) were much lower than those in the controls( P <0.01). CONCLUSION:The aged impaired glucose tolerance patients should be protected from damages of β cell function and intervention of hyperlipidemia should be undertaken as early as possible.

关 键 词：老年人 糖耐量低减 冠状动脉疾病 Β细胞功能 脂代谢 

分 类 号：R541.4[医药卫生—心血管疾病]