冲击伤及偏二甲基肼与四氧化二氮吸入致冲毒复合伤大鼠血气的变化  

The changes of blood gas after the blast-chemical com bined injury caused by the blast injury and nitrogen tetroxide and unsymmetrical dimethylhydrazine inspiration

作　　者：杨鹤鸣[1] 岳茂兴[1] 夏亚东[2] 王德文[2] 杨志焕[3] 王正国[3] 李建忠[1] 徐世全[1] 彭瑞云[3] 

机构地区：[1]中国人民解放军第306医院,北京100101 [2]中国人民军事医学科学院,北京100101 [3]中国人民解放军第三军医大学野战外科研究所,重庆400042

出　　处：《中华航空航天医学杂志》2001年第3期172-175,共4页Chinese Journal of Aerospace Medicine

摘　　要：目的　复制四氧化二氮 (N2 O4)及偏二甲基肼 (U DMH)混合气体爆炸致冲毒复合伤模型 ,并研究了该模型致伤后大鼠血气的变化。　方法　采用健康雄性 Wistar大鼠 ,先置于生物激波管冲击致伤。然后置于自制染毒柜 ,先后吸入 U DMH及 N2 O4,吸入时间均为 15 m in。造成中至重度冲毒复合伤模型。在伤前、伤后 3、6、12、2 4、48和 72 h右颈总动脉插管 ,抽取动脉血 ,进行血气分析。　结果　冲击伤及偏二甲基肼与四氧化二氮同时吸入致冲毒复合伤动脉血氧分压下降持续时间最长 ,下降最为显著 ,恢复较前两组慢。p H值变化与此类似。　结论　冲击伤合并 UDMH及 N2 O4气体同时中毒对血气的影响较冲击伤加单一气体中毒变化显著 ;Objective To investigate the changes of blood gas in blast-chemical combined injury model of the explosion of the mixed gas of n itrogen tetroxide(N 2O 4) and unsymmetrical dimethylhydrazine (UDMH). Met hods Two hundred and twenty four Wistar rats were divided randomly into 1.control group (C), 2 blast + UDMH intoxication injury group (BU), 3.blast + N 2O 4 intoxication injury group (BN), 4.blast + UDMH and N 2O 4 intoxicatio n group (BUN). BST-1 blast tube was used to induce blast injury, and toxic gase s were given to corresponding groups of rats through inhalation in an intoxicati on tank for 15 min. The clinical states of experimental rats were observed and t he animals were killed subsequently 3, 6, 12, 24, 48 and 72 h later for blood an alysis. Results As compared with C group, the lowering of arte rial blood PO 2 , SO 2 and pH in rats of BUN group was the most prominent, a nd the sustaining time of changes of blood gas was the longest in 3 experimental groups. Conclusions Blast-UDMH and N 2O 4 combined injury affe ct the blood gas more significantly than that of a single-agent induced blast- chemical combined injury. The injury of respiration tract especially the lung w as the main cause of the changes of blood gas after the blast-chemical combined injury.

关 键 词：偏二甲基肼 四氧化二氮 爆震伤 气体中毒 血气分析 

分 类 号：R858.3[医药卫生—航空、航天与航海医学] R642[医药卫生—临床医学]