经静脉心肌声学造影剂的研制  

Preparation study of intravenous myocardial contrast agent

作　　者：唐晓明[1] 钱学贤[1] 吴志坚[1] 刘磊[1] 靳亚菲[1] 彭榕[1] 

机构地区：[1]第一军医大学第二附属医院心内科,广东广州510282

出　　处：《心脏杂志》2001年第6期435-439,共5页Chinese Heart Journal

基　　金：广东省"五个一科教兴医工程"重点项目分题

摘　　要：目的 :制备可经静脉注射产生心肌对比增强效果的声学对比造影剂 ,观察其心肌显影效果。方法 :1按不同比例将 5 0 g· L- 1 葡萄糖或 9g· L- 1 Na Cl,C3 F8气体与人血白蛋白混合后进行超声振荡。 Coulter' s计数器对造影剂进行质量分析。 2经犬股静脉注射自制对比造影剂 0 .2 ml,经胸壁扫查犬左室乳头肌水平短轴切面。结果 :1造影剂微泡液的相对浓度为 4 .2 3 9× 10 9/m l,微泡平均直径 3 .789μm,小于 9.89μm微泡占 99.5 %。 2经静脉注射后 ,均产生不同程度的心肌对比增强效果 ,心肌显影持续时间 1～ 3 min。注射前后犬血流动力学无显著性改变。结论 :自制经静脉注射对比造影剂符合心肌声学造影的要求 ;初步动物实验表明经静脉注射可产生肉眼可辨的心肌显影 ;AIM: To develop a newly developed of echo contrast agent (code name: FCT 188) that can produce myocardial contrast after intravenous injection. METHODS: Admixtures comprise diverse proportions of 50 g·L -1 dextrose, 9 g·L -1 NaCl, C3F8 gas and human albumin were sonicated with different sonicating conditions. The microbubble solution was assessed by Coulter's counter. MCE with short axis view of left ventricular was performed in 3 Mongrel dogs. 0.2 ml of FCT 188 was injected into femoral vein. RESULTS: The relative concentration of the prepared microbubbles was 4.239×10 9/mL with mean diameters 3.789 μm. All the case showed intense myocardium contrast image which lasted for 1~3 min after intravenous injection. CONCLUSION: The echo contrast agent prepared in our laboratory accord with the essential conditions of MCE. Visual identification myocardium contrast image can be created after intravenous injection.

关 键 词：超声心动描记术 对比造影 狗 心肌 静脉注射 声学造影剂 

分 类 号：R816.2[医药卫生—放射医学] R540.45[医药卫生—临床医学]