伪麻黄碱和麻黄碱对大鼠肛尾肌作用机理的研究  

EFFECTS OF PSEUDO-EPHEDRINE AND EPHEDRINE ON ISOLATED RAT ANOCOCCYGEUS MUCSLES

作　　者：戴贵东[1] 李汉青[1] 

机构地区：[1]宁夏医学院药理教研室,宁夏银川750004

出　　处：《华西药学杂志》2001年第6期425-426,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :比较研究伪麻黄碱 (p Eph)和麻黄碱 (Eph)对大鼠肛尾肌的作用机理。方法 :大鼠肛尾肌离体实验。结果 :p Eph浓度依赖性收缩大鼠离体肛尾肌。经育亨宾、哌唑嗪预处理标本和利血平化 (按 1mg·kg 1,ip ,实验前 48h和 2 4h)大鼠后 ,伪麻黄碱的正性肌力作用显著减弱。麻黄碱也有类似的作用 ,但利血平化大鼠后 ,不影响其正性肌力作用。结论 :同等浓度下 ,p Eph以间接作用方式激动大鼠肛尾肌α1和α2 受体而产生正性肌力作用 。OBJECTIVE:To compare the effects between pseudo Ephedrine(p Eph) and Ephedrine (Eph) to rat anococcygeus musles. METHODS: Isolated rats anococcygeus muscles were used. The contractile responses were recorded on forcetransducer and pen recorder. RERULTS: Pseudo ephedrine (p Eph),dose dependently contracted rats anococcygeus muscles, which were inhibited by reserpine, yohimbine and prazosin pretreatment respectively; Ephedrine (Eph),had the similar actions except being not affected by reserpinization. CONCLUSION: At the same concentration, p Eph active α 1 and α 2 receptors on anococcygeus muscles in rats with indirect action, but Eph with direct.

关 键 词：伪麻黄碱 麻黄碱 肛尾肌 作用机理 正性肌力作用 实验研究 

分 类 号：R285.5[医药卫生—中药学]